UniProt Accession

 MND1_HUMAN; Q9BWT6; B2R5F9 

Genbank Protein ID

 AY028916; AK312172; CH471056; CH471056; BC032142 

Genbank Nucleotide ID

 AAK26168.1; BAG35106.1; EAX04964.1; EAX04965.1; AAH32142.1 

Protein Name

 Meiotic nuclear division protein 1 homolog 

Protein Synonyms/Alias

  

Gene Name

 MND1 

Gene Synonyms/Alias

 GAJ 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	TKDVFQLKDLEKIAP	ubiquitination	[1, 2]
77	YYWAFPSKALHARKH	ubiquitination	[3]
177	TDNIFAIKSWAKRKF	ubiquitination	[3, 4]
190	KFGFEENKIDRTFGI	ubiquitination	[5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. 

Sequence Annotation

  

Keyword

 Coiled coil; Complete proteome; DNA recombination; DNA-binding; Meiosis; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0007126; P:meiosis; IEA:UniProtKB-KW. 

Interpro

 IPR005647; Mnd1.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF03962; Mnd1 

SMART

  

PROSITE

  

PRINTS