CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039922
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tetratricopeptide repeat protein 7A 
Protein Synonyms/Alias
  
Gene Name
 TTC7A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
162KQDELHRKALQTLERubiquitination[1]
206EQLQEALKVRKDDAHubiquitination[2]
301FGEGLTMKKQSGMHLubiquitination[2]
302GEGLTMKKQSGMHLTubiquitination[1]
404RGRLAEVKGNLEEAKubiquitination[1, 3]
411KGNLEEAKQLYKEALubiquitination[1, 2, 4]
415EEAKQLYKEALTVNPubiquitination[1]
441MLSRLGHKSLAQKVLubiquitination[2]
446GHKSLAQKVLRDAVEubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MATRDVVLSR VPEQEEDRTV SLQNAAAIYD LLSITLGRRG QYVMLSECLE RAMKFAFGEF 60
HLWYQVALSM VACGKSAYAV SLLRECVKLR PSDPTVPLMA AKVCIGSLRW LEEAEHFAMM 120
VISLGEEAGE FLPKGYLALG LTYSLQATDA TLKSKQDELH RKALQTLERA QQLAPSDPQV 180
ILYVSLQLAL VRQISSAMEQ LQEALKVRKD DAHALHLLAL LFSAQKHHQH ALDVVNMAIT 240
EHPENFNLMF TKVKLEQVLK GPEEALVTCR QVLRLWQTLY SFSQLGGLEK DGSFGEGLTM 300
KKQSGMHLTL PDAHDADSGS RRASSIAASR LEEAMSELTM PSSVLKQGPM QLWTTLEQIW 360
LQAAELFMEQ QHLKEAGFCI QEAAGLFPTS HSVLYMRGRL AEVKGNLEEA KQLYKEALTV 420
NPDGVRIMHS LGLMLSRLGH KSLAQKVLRD AVERQSTCHE AWQGLGEVLQ AQGQNEAAVD 480
CFLTALELEA SSPVLPFSII PREL 504 
Gene Ontology
 GO:0006879; P:cellular iron ion homeostasis; IEA:Compara.
 GO:0030097; P:hemopoiesis; IEA:Compara. 
Interpro
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat.
 IPR026900; Ttc7. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS