CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012236
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cyclin-I 
Protein Synonyms/Alias
  
Gene Name
 CCNI 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2******MKFPGPLENubiquitination[1, 2]
18RLSFLLEKAITREAQubiquitination[3, 4]
28TREAQMWKVNVRKMPubiquitination[1, 2, 3, 4]
33MWKVNVRKMPSNQNVubiquitination[3]
54EVIQWLAKLKYQFNLubiquitination[3]
112DERIPVLKVLARDSFubiquitination[3, 4]
266VYVYRPLKHTLVTCDubiquitination[4]
274HTLVTCDKGVFRLHPubiquitination[4]
291VPGPDFSKDNSKPEVubiquitination[4]
295DFSKDNSKPEVPVRGubiquitination[3, 4]
324KQTSTKRKVEEMEVDubiquitination[4]
338DDFYDGIKRLYNEDNubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Cyclin; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MKFPGPLENQ RLSFLLEKAI TREAQMWKVN VRKMPSNQNV SPSQRDEVIQ WLAKLKYQFN 60
LYPETFALAS SLLDRFLATV KAHPKYLSCI AISCFFLAAK TVEEDERIPV LKVLARDSFC 120
GCSSSEILRM ERIILDKLNW DLHTATPLDF LHIFHAIAVS TRPQLLFSLP KLSPSQHLAV 180
LTKQLLHCMA CNQLLQFRGS MLALAMVSLE MEKLIPDWLS LTIELLQKAQ MDSSQLIHCR 240
ELVAHHLSTL QSSLPLNSVY VYRPLKHTLV TCDKGVFRLH PSSVPGPDFS KDNSKPEVPV 300
RGTAAFYHHL PAASGCKQTS TKRKVEEMEV DDFYDGIKRL YNEDNVSENV GSVCGTDLSR 360
QEGHASPCPP LQPVSVM 377 
Gene Ontology
 GO:0007283; P:spermatogenesis; NAS:UniProtKB. 
Interpro
 IPR013763; Cyclin-like.
 IPR006671; Cyclin_N. 
Pfam
 PF00134; Cyclin_N 
SMART
 SM00385; CYCLIN 
PROSITE
 PS00292; CYCLINS 
PRINTS