CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015976
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 mTERF domain-containing protein 2 
Protein Synonyms/Alias
 Mitochondrial transcription termination factor 4; MTERF4 
Gene Name
 MTERFD2 
Gene Synonyms/Alias
 HSPC096 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
168KRSSYLQKLGLGEGKubiquitination[1]
291QIPNPLLKDILRVSEubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Required for the targeting of the methyltransferase NSUN4 to mitochondrial large ribosomal subunit and efficient rRNA methylation. 
Sequence Annotation
 REPEAT 142 172 MTERF 1.
 REPEAT 177 204 MTERF 2.
 REPEAT 209 239 MTERF 3.
 REPEAT 245 270 MTERF 4.
 REPEAT 290 318 MTERF 5.
 REGION 310 327 Dimerization with NSUN4.  
Keyword
 3D-structure; Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Repeat; RNA-binding; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 381 AA 
Protein Sequence
MAAFGRQVLD WHRLIPLTWA CMARQTPHLG EQRRTTASLL RKLTTASNGG VIEELSCVRS 60
NNYVQEPECR RNLVQCLLEK QGTPVVQGSL ELERVMSSLL DMGFSNAHIN ELLSVRRGAS 120
LQQLLDIISE FILLGLNPEP VCVVLKKSPQ LLKLPIMQMR KRSSYLQKLG LGEGKLKRVL 180
YCCPEIFTMR QQDINDTVRL LKEKCLFTVQ QVTKILHSCP SVLREDLGQL EYKFQYAYFR 240
MGIKHPDIVK SEYLQYSLTK IKQRHIYLER LGRYQTPDKK GQTQIPNPLL KDILRVSEAE 300
FLARTACTSV EEFQVFKKLL AREEEESESS TSDDKRASLD EDEDDDDEED NDEDDNDEDD 360
DDEDDDEAED NDEDEDDDEE E 381 
Gene Ontology
 GO:0005762; C:mitochondrial large ribosomal subunit; IDA:MGI.
 GO:0019843; F:rRNA binding; IDA:MGI.
 GO:0043010; P:camera-type eye development; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0006626; P:protein targeting to mitochondrion; IEA:Compara.
 GO:0042255; P:ribosome assembly; IEA:Compara.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
 GO:0006390; P:transcription from mitochondrial promoter; IEA:Compara. 
Interpro
 IPR003690; Mit_transcrip_term-rel. 
Pfam
 PF02536; mTERF 
SMART
 SM00733; Mterf 
PROSITE
  
PRINTS