CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014607
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Syntaxin-binding protein 2 
Protein Synonyms/Alias
 MUSEC1; Protein unc-18 homolog 2; Munc18-2; Unc18-2; Protein unc-18 homolog B; Unc-18B 
Gene Name
 Stxbp2 
Gene Synonyms/Alias
 Unc18b 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
494VEDRLDRKLWPFVSDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N- ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Exocytosis; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 593 AA 
Protein Sequence
MAPLGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED 60
INKRREPIPS LEAIYLLSPT EKSVQALIAD FQGTPTFTYK AAHIFFTDTC PEPLFSELGR 120
SRLAKAVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RAGERGRQLD ALAQQIATLC 180
ATLQEYPSIR YRKGPEDTAQ LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV 240
SPLLHELTFQ AMAYDLLDIE QDTYRYETTG LSESREKAVL LDEDDDLWVE LRHMHIADVS 300
KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS 360
VEKLCSVEQD LAMGSDAEGE KIKDAMKLIV PVLLDASVPP YDKIRVLLLY ILLRNGVSEE 420
NLAKLIQHAN VQSYSSLIRN LEQLGGTVTN SAGSGTSSRL ERRERMEPTY QLSRWSPVIK 480
DVMEDVVEDR LDRKLWPFVS DPAPVPSSQA AVSARFGHWH KNKAGVEARA GPRLIVYIVG 540
GVAMSEMRAA YEVTRATEGK WEVLIGSSHI LTPTRFLDDL KTLDQKLEGV ALP 593 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0042582; C:azurophil granule; IEA:Compara.
 GO:0044194; C:cytolytic granule; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0031201; C:SNARE complex; IEA:Compara.
 GO:0042581; C:specific granule; IEA:Compara.
 GO:0070820; C:tertiary granule; IEA:Compara.
 GO:0019905; F:syntaxin binding; TAS:MGI.
 GO:0006887; P:exocytosis; IMP:MGI.
 GO:0001909; P:leukocyte mediated cytotoxicity; IEA:Compara.
 GO:0043312; P:neutrophil degranulation; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro. 
Interpro
 IPR027482; Sec-1-like_dom2.
 IPR001619; Sec1-like. 
Pfam
 PF00995; Sec1 
SMART
  
PROSITE
  
PRINTS