UniProt Accession

 ANXA2_SHEEP; A2SW69 

Genbank Protein ID

 DQ358998 

Genbank Nucleotide ID

 ABC94470.1 

Protein Name

 Annexin A2 

Protein Synonyms/Alias

 Annexin-2 

Gene Name

 ANXA2 

Gene Synonyms/Alias

 ANX2 

Created Date

 July 27, 2013 

Organism

 Ovis aries (Sheep) 

NCBI Taxa ID

 9940 

Lysine Modification

Position	Peptide	Type	References
104	TVILGLLKTPAQYDA	ubiquitination	[1]

Reference

 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048] 

Functional Description

 Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity (By similarity). 

Sequence Annotation

 REPEAT 42 102 Annexin 1.
 REPEAT 114 174 Annexin 2.
 REPEAT 199 259 Annexin 3.
 REPEAT 274 334 Annexin 4.
 REGION 2 24 S100A10-binding site (Potential).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 24 24 Phosphotyrosine; by SRC (By similarity).
 MOD_RES 26 26 Phosphoserine; by PKC (By similarity).  

Keyword

 Acetylation; Annexin; Basement membrane; Calcium; Calcium/phospholipid-binding; Extracellular matrix; Phosphoprotein; Repeat; Secreted; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 339 AA 

Protein Sequence

Gene Ontology

 GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0004859; F:phospholipase inhibitor activity; IEA:InterPro. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002389; AnnexinII. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR00198; ANNEXINII.