UniProt Accession

 IRF6_HUMAN; O14896; B4DLE2; D3DT90; F5GWX8; G0ZTL0 

Genbank Protein ID

 AF027292; JF346417; AK296960; AL022398; CH471100; CH471100; BC014852 

Genbank Nucleotide ID

 AAB84111.1; AEL89176.1; BAG59504.1; CAA18545.1; EAW93438.1; EAW93439.1; AAH14852.1 

Protein Name

 Interferon regulatory factor 6 

Protein Synonyms/Alias

 IRF-6 

Gene Name

 IRF6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	AWAVETGKYQEGVDD	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). 

Sequence Annotation

 DNA_BIND 7 115 IRF tryptophan pentad repeat.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Differentiation; Disease mutation; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 467 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0000975; F:regulatory region DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0007050; P:cell cycle arrest; IDA:UniProtKB.
 GO:0048468; P:cell development; IEA:Compara.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0043616; P:keratinocyte proliferation; IEA:Compara.
 GO:0060644; P:mammary gland epithelial cell differentiation; ISS:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0043588; P:skin development; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR019817; Interferon_reg_fac_CS.
 IPR001346; Interferon_reg_fact_DNA-bd_dom.
 IPR019471; Interferon_reg_factor-3.
 IPR017855; SMAD_dom-like.
 IPR008984; SMAD_FHA_domain.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00605; IRF
 PF10401; IRF-3 

SMART

 SM00348; IRF 

PROSITE

 PS00601; IRF_1
 PS51507; IRF_2 

PRINTS

 PR00267; INTFRNREGFCT.