Tag | Content |
---|
CPLM ID | CPLM-018227 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dehydrogenase/reductase SDR family member 4 |
Protein Synonyms/Alias | NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; CR; PHCR; NADPH-dependent retinol dehydrogenase/reductase; NDRD; Peroxisomal short-chain alcohol dehydrogenase; PSCD |
Gene Name | Dhrs4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
---|
93 | GVVCHVGKAEDREKL | acetylation | [1] | 99 | GKAEDREKLVNMALK | acetylation | [1] | 159 | AVVPAMEKRGGGSVV | acetylation | [1] | 204 | FAAELAPKNIRVNCL | acetylation | [1] | 226 | HFSSVLWKEKAREEM | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). |
Sequence Annotation | NP_BIND 37 61 NADP (By similarity). MOTIF 277 279 Microbody targeting signal. ACT_SITE 183 183 Proton acceptor (By similarity). BINDING 170 170 Substrate (By similarity). |
Keyword | Complete proteome; NADP; Oxidoreductase; Peroxisome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 279 AA |
Protein Sequence | MQKAGLLLRG WTRAWKSVRM ASSGLTRQNP LANKVALVTA STDGIGLAIA RRLAEDGAHV 60 VISSRKQQNV DRAVATLQGE GLSVTGVVCH VGKAEDREKL VNMALKLHQG IDILVSNAAV 120 NPFFGNLMDV TEEVWNKVLS INVTASAMMI KAVVPAMEKR GGGSVVIVSS VAGFVLFPSL 180 GPYNVSKTAL LGLTKNFAAE LAPKNIRVNC LAPGLIKTHF SSVLWKEKAR EEMIKETMQI 240 RRLGKPEDCV GIVSFLCSED ASYINGETVV VGGGTPSRL 279 |
Gene Ontology | GO:0005739; C:mitochondrion; ISS:UniProtKB. GO:0005777; C:peroxisome; IDA:RGD. GO:0004090; F:carbonyl reductase (NADPH) activity; IEA:EC. GO:0001758; F:retinal dehydrogenase activity; IEA:Compara. GO:0042574; P:retinal metabolic process; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |