| Tag | Content |
|---|
| CPLM ID | CPLM-018997 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nicalin |
Protein Synonyms/Alias | Nicastrin-like protein |
Gene Name | NCLN |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 99 | FSYEQYQKALRQSAG | ubiquitination | [1] | | 194 | VTSGVQSKAVSDWLI | ubiquitination | [1] | | 409 | VRSRVDSKTLTRNTR | ubiquitination | [1] | | 510 | FVFYDQLKQVMNAYR | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning (By similarity). |
Sequence Annotation | CARBOHYD 241 241 N-linked (GlcNAc...) (Potential).
CARBOHYD 428 428 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Complete proteome; Endoplasmic reticulum; Glycoprotein; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 563 AA |
Protein Sequence | MLEEAGEVLE NMLKASCLPL GFIVFLPAVL LLVAPPLPAA DAAHEFTVYR MQQYDLQGQP 60
YGTRNAVLNT EARTMAAEVL SRRCVLMRLL DFSYEQYQKA LRQSAGAVVI ILPRAMAAVP 120
QDVVRQFMEI EPEMLAMETA VPVYFAVEDE ALLSIYKQTQ AASASQGSAS AAEVLLRTAT 180
ANGFQMVTSG VQSKAVSDWL IASVEGRLTG LGGEDLPTIV IVAHYDAFGV APWLSLGADS 240
NGSGVSVLLE LARLFSRLYT YKRTHAAYNL LFFASGGGKF NYQGTKRWLE DNLDHTDSSL 300
LQDNVAFVLC LDTVGRGSSL HLHVSKPPRE GTLQHAFLRE LETVAAHQFP EVRFSMVHKR 360
INLAEDVLAW EHERFAIRRL PAFTLSHLES HRDGQRSSIM DVRSRVDSKT LTRNTRIIAE 420
ALTRVIYNLT EKGTPPDMPV FTEQMIQQEQ LDSVMDWLTN QPRAAQLVDK DSTFLSTLEH 480
HLSRYLKDVK QHHVKADKRD PEFVFYDQLK QVMNAYRVKP AVFDLLLAVG IAAYLGMAYV 540
AVQHFSLLYK TVQRLLVKAK TQ 562 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:HPA. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IDA:HPA. GO:0008233; F:peptidase activity; IEA:InterPro. GO:0006508; P:proteolysis; IEA:InterPro. GO:0009966; P:regulation of signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |