UniProt Accession

 ACAD9_HUMAN; Q9H845; D3DNB8; Q8WXX3 

Genbank Protein ID

 AF327351; AK024012; CH471052; CH471052; BC013354; BC007970 

Genbank Nucleotide ID

 AAL56011.1; BAB14775.1; EAW79295.1; EAW79296.1; AAH13354.1; AAH07970.1 

Protein Name

 Acyl-CoA dehydrogenase family member 9, mitochondrial 

Protein Synonyms/Alias

 ACAD-9 

Gene Name

 ACAD9 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
41	PPVRAFAKELFLGKI	acetylation	[1]
599	ENLDEQIKKVSQQIL	ubiquitination	[2]
608	VSQQILEKRAYICAH	acetylation	[1]
608	VSQQILEKRAYICAH	ubiquitination	[2, 3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA than on stearoyl-CoA. Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0). 

Sequence Annotation

 ACT_SITE 426 426 Proton acceptor (By similarity).
 MOD_RES 41 41 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 621 AA 

Protein Sequence

Gene Ontology

 GO:0030425; C:dendrite; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IDA:LIFEdb.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:InterPro.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. 

Interpro

 IPR006089; Acyl-CoA_DH_CS.
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase. 

Pfam

 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N 

SMART

  

PROSITE

 PS00072; ACYL_COA_DH_1
 PS00073; ACYL_COA_DH_2 

PRINTS