UniProt Accession

 CHM1A_MOUSE; Q921W0; Q3TW57 

Genbank Protein ID

 AK046416; AK159830; BC010524; BC023807; BC036138; BC036152 

Genbank Nucleotide ID

 BAC32719.1; BAE35409.1; AAH10524.1; AAH23807.1; AAH36138.1; AAH36152.1 

Protein Name

 Charged multivesicular body protein 1a 

Protein Synonyms/Alias

 Chromatin-modifying protein 1a; CHMP1a 

Gene Name

 Chmp1a 

Gene Synonyms/Alias

 Chmp1; Pcoln3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
17	FTAKQLEKLAKKAEK	acetylation	[1]
20	KQLEKLAKKAEKDSK	acetylation	[1]
55	YAENAIRKKNEGVNW	ubiquitination	[2]
56	AENAIRKKNEGVNWL	ubiquitination	[2]
83	VQTAVTMKGVTKNMA	ubiquitination	[2]

Reference

 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing (By similarity). 

Sequence Annotation

 MOTIF 185 195 MIT-interacting motif.
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Endosome; Membrane; Nucleus; Protein transport; Reference proteome; Repressor; Transcription; Transcription regulation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 196 AA 

Protein Sequence

Gene Ontology

 GO:0000794; C:condensed nuclear chromosome; ISS:UniProtKB.
 GO:0005769; C:early endosome; ISS:UniProtKB.
 GO:0012505; C:endomembrane system; ISS:UniProtKB.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005815; C:microtubule organizing center; ISS:UniProtKB.
 GO:0016363; C:nuclear matrix; ISS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0016458; P:gene silencing; ISS:UniProtKB.
 GO:0007076; P:mitotic chromosome condensation; ISS:UniProtKB.
 GO:0045014; P:negative regulation of transcription by glucose; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0016192; P:vesicle-mediated transport; IEA:Compara. 

Interpro

 IPR005024; Snf7. 

Pfam

 PF03357; Snf7 

SMART

  

PROSITE

  

PRINTS