CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009571
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ras-related protein Rab-3C 
Protein Synonyms/Alias
  
Gene Name
 Rab3c 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
74FKVKTVFKNEKRIKLacetylation[1]
181AKDNINVKQTFERLVacetylation[1]
181AKDNINVKQTFERLVubiquitination[2]
209DPAITAAKQSTRLKEubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 Protein transport. Probably involved in vesicular traffic (By similarity). 
Sequence Annotation
 NP_BIND 37 44 GTP (By similarity).
 NP_BIND 85 89 GTP (By similarity).
 NP_BIND 143 146 GTP (By similarity).
 MOTIF 59 67 Effector region (By similarity).
 MOD_RES 227 227 Cysteine methyl ester (By similarity).
 LIPID 225 225 S-geranylgeranyl cysteine (By
 LIPID 227 227 S-geranylgeranyl cysteine (By  
Keyword
 Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 227 AA 
Protein Sequence
MRHEAPMQMA SAQDARFGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY ADDSFTSAFV 60
STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY RGAMGFILMY DITNEESFNA 120
VQDWSTQIKT YSWDNAQVIL AGNKCDMEDE RVVSTERGQR LGEQLGFEFF ETSAKDNINV 180
KQTFERLVDI ICDKMSESLE TDPAITAAKQ STRLKETPPP PQPNCGC 227 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0017156; P:calcium ion-dependent exocytosis; TAS:RGD.
 GO:0007269; P:neurotransmitter secretion; TAS:RGD.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0017157; P:regulation of exocytosis; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 
Pfam
 PF00071; Ras 
SMART
 SM00175; RAB 
PROSITE
 PS51419; RAB 
PRINTS
 PR00449; RASTRNSFRMNG.