CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017825
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Di-N-acetylchitobiase 
Protein Synonyms/Alias
  
Gene Name
 Ctbs 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
328SLKAAYVKNYGLRGIacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase (By similarity). 
Sequence Annotation
 ACT_SITE 127 127 Proton donor (By similarity).
 CARBOHYD 131 131 N-linked (GlcNAc...) (Potential).
 CARBOHYD 177 177 N-linked (GlcNAc...) (Potential).
 CARBOHYD 212 212 N-linked (GlcNAc...) (Potential).
 CARBOHYD 246 246 N-linked (GlcNAc...) (Potential).
 CARBOHYD 283 283 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Glycosidase; Hydrolase; Lysosome; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 366 AA 
Protein Sequence
MALCGLPEFT LLLLPLLARL SAGDCPCSEA ALCQPIRHRP DFEVFVFDVG QKTWKSYDWS 60
QITTVAAFGK YDPELMCYAH SKGARVVLKG DISLKNIIDP TFRASWIAQK VDLAKAQYMD 120
GINIDIEQEV NCSSPEYEAL TALVKETTES FQREIEGSQV TFDVAWSPKR IDKRCYNYTG 180
IADACDFLFV MSYDEQSQIW SECIAAANAP YNQTLTGYID YIKMGISPKK LVMGVPWYGY 240
DYICLNLSKD DICTITKVPF RGAPCSDAAG HQVPYKVIMK QVNGSVSGSQ WNKDQQAPYY 300
NYKDPAGRFH QVWYDNPQSI SLKAAYVKNY GLRGIGMWNA NCLDYSDDAL AREQTQEMWG 360
ALKPRL 366 
Gene Ontology
 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0004568; F:chitinase activity; IEA:Compara.
 GO:0006032; P:chitin catabolic process; IEA:Compara.
 GO:0009313; P:oligosaccharide catabolic process; IEA:Compara. 
Interpro
 IPR011583; Chitinase_II.
 IPR001223; Glyco_hydro18cat.
 IPR001579; Glyco_hydro_18_chit_AS.
 IPR013781; Glyco_hydro_catalytic_dom.
 IPR017853; Glycoside_hydrolase_SF. 
Pfam
 PF00704; Glyco_hydro_18 
SMART
 SM00636; Glyco_18 
PROSITE
 PS01095; CHITINASE_18 
PRINTS