| Tag | Content |
|---|
| CPLM ID | CPLM-007791 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium-activated aldehyde dehydrogenase, mitochondrial |
Protein Synonyms/Alias | K(+)-activated acetaldehyde dehydrogenase; K(+)-ACDH |
Gene Name | ALD4 |
Gene Synonyms/Alias | ALD7; ALDH2; YOR374W; O6730 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 52 | TGLFINNKFVPSKQN | acetylation | [1] | | 260 | EAITNHPKIKKVAFT | acetylation | [1] | | 263 | TNHPKIKKVAFTGST | acetylation | [1] | | 306 | VFADAELKKAVQNII | acetylation | [1] | | 345 | DKFIEEFKAASESIK | acetylation | [1] | | 374 | TSQMQLNKILKYVDI | acetylation | [1] | | 377 | MQLNKILKYVDIGKN | acetylation | [1] | | 383 | LKYVDIGKNEGATLI | acetylation | [1] | | 399 | GGERLGSKGYFIKPT | acetylation | [1] | | 404 | GSKGYFIKPTVFGDV | acetylation | [1] | | 412 | PTVFGDVKEDMRIVK | acetylation | [1] | | 431 | GPVVTVTKFKSADEV | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | |
Sequence Annotation | NP_BIND 268 273 NAD (By similarity).
ACT_SITE 290 290 Proton acceptor (By similarity).
ACT_SITE 324 324 Nucleophile (By similarity).
MOD_RES 96 96 Phosphoserine.
MOD_RES 216 216 Phosphothreonine.
MOD_RES 500 500 Phosphoserine. |
Keyword | Complete proteome; Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 519 AA |
Protein Sequence | MFSRSTLCLK TSASSIGRLQ LRYFSHLPMT VPIKLPNGLE YEQPTGLFIN NKFVPSKQNK 60
TFEVINPSTE EEICHIYEGR EDDVEEAVQA ADRAFSNGSW NGIDPIDRGK ALYRLAELIE 120
QDKDVIASIE TLDNGKAISS SRGDVDLVIN YLKSSAGFAD KIDGRMIDTG RTHFSYTKRQ 180
PLGVCGQIIP WNFPLLMWAW KIAPALVTGN TVVLKTAEST PLSALYVSKY IPQAGIPPGV 240
INIVSGFGKI VGEAITNHPK IKKVAFTGST ATGRHIYQSA AAGLKKVTLE LGGKSPNIVF 300
ADAELKKAVQ NIILGIYYNS GEVCCAGSRV YVEESIYDKF IEEFKAASES IKVGDPFDES 360
TFQGAQTSQM QLNKILKYVD IGKNEGATLI TGGERLGSKG YFIKPTVFGD VKEDMRIVKE 420
EIFGPVVTVT KFKSADEVIN MANDSEYGLA AGIHTSNINT ALKVADRVNA GTVWINTYND 480
FHHAVPFGGF NASGLGREMS VDALQNYLQV KAVRAKLDE 519 |
Gene Ontology | GO:0042645; C:mitochondrial nucleoid; IDA:SGD. GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IDA:SGD. GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IDA:SGD. GO:0019413; P:acetate biosynthetic process; IGI:SGD. GO:0006067; P:ethanol metabolic process; IMP:SGD. GO:0006740; P:NADPH regeneration; IGI:SGD. GO:0006090; P:pyruvate metabolic process; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |