CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002994
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoribosylaminoimidazole-succinocarboxamide synthase 
Protein Synonyms/Alias
 SAICAR synthetase 
Gene Name
 purC 
Gene Synonyms/Alias
 b2476; JW2461 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
52RKGMVNNKFNYFIMSacetylation[1]
60FNYFIMSKLAEAGIPacetylation[1]
82SDTECLVKKLDMVPVacetylation[1]
103RAAGSLVKRLGIEEGacetylation[1]
145ETFGWVSKENLARMKacetylation[1]
152KENLARMKELTYKANacetylation[1]
157RMKELTYKANDVLKKacetylation[1]
163YKANDVLKKLFDDAGacetylation[1]
164KANDVLKKLFDDAGLacetylation[1]
203DGSRLWDKETLEKMDacetylation[1]
208WDKETLEKMDKDRFRacetylation[1]
211ETLEKMDKDRFRQSLacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
  
Keyword
 3D-structure; ATP-binding; Complete proteome; Direct protein sequencing; Ligase; Nucleotide-binding; Purine biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 237 AA 
Protein Sequence
MQKQAELYRG KAKTVYSTEN PDLLVLEFRN DTSAGDGARI EQFDRKGMVN NKFNYFIMSK 60
LAEAGIPTQM ERLLSDTECL VKKLDMVPVE CVVRNRAAGS LVKRLGIEEG IELNPPLFDL 120
FLKNDAMHDP MVNESYCETF GWVSKENLAR MKELTYKAND VLKKLFDDAG LILVDFKLEF 180
GLYKGEVVLG DEFSPDGSRL WDKETLEKMD KDRFRQSLGG LIEAYEAVAR RLGVQLD 237 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IDA:EcoCyc.
 GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR013816; ATP_grasp_subdomain_2.
 IPR001636; SAICAR_synth.
 IPR018236; SAICAR_synthetase_CS. 
Pfam
 PF01259; SAICAR_synt 
SMART
  
PROSITE
 PS01057; SAICAR_SYNTHETASE_1
 PS01058; SAICAR_SYNTHETASE_2 
PRINTS