UniProt Accession

 NEUR3_MOUSE; Q9JMH7 

Genbank Protein ID

 AB026842 

Genbank Nucleotide ID

 BAA92868.1 

Protein Name

 Sialidase-3 

Protein Synonyms/Alias

 Ganglioside sialidase; Membrane sialidase; N-acetyl-alpha-neuraminidase 3 

Gene Name

 Neu3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
154	EVIGSEVKRWATFAV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates (By similarity). 

Sequence Annotation

 REPEAT 129 140 BNR 1.
 REPEAT 203 214 BNR 2.
 REPEAT 254 265 BNR 3.
 MOTIF 24 27 FRIP motif.
 ACT_SITE 50 50 Proton acceptor (By similarity).
 ACT_SITE 369 369 Nucleophile (By similarity).
 ACT_SITE 386 386 Potential.
 BINDING 25 25 Substrate (By similarity).
 BINDING 243 243 Substrate (Potential).
 BINDING 339 339 Substrate (By similarity).  

Keyword

 Complete proteome; Glycosidase; Hydrolase; Membrane; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 418 AA 

Protein Sequence

Gene Ontology

 GO:0005886; C:plasma membrane; ISA:MGI.
 GO:0016997; F:alpha-sialidase activity; ISA:MGI.
 GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:EC.
 GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:EC.
 GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:EC.
 GO:0005975; P:carbohydrate metabolic process; ISA:MGI. 

Interpro

 IPR026944; Sialidase-3.
 IPR026856; Sialidase_fam.
 IPR011040; Sialidases. 

Pfam

  

SMART

  

PROSITE

  

PRINTS