UniProt Accession

 B0LPF3_HUMAN; B0LPF3 

Genbank Protein ID

 EU332843; JX512444; AK315565; CH471099 

Genbank Nucleotide ID

 ABY87532.1; AGC09591.1; BAG37940.1; EAW89270.1 

Protein Name

 Growth factor receptor-bound protein 2 

Protein Synonyms/Alias

 Growth factor receptor-bound protein 2, isoform CRA_a; cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA 

Gene Name

 GRB2 

Gene Synonyms/Alias

 hCG_27179 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	ADDELSFKRGDILKV	ubiquitination	[1]
44	YKAELNGKDGFIPKN	ubiquitination	[1, 2]
56	PKNYIEMKPHPWFFG	ubiquitination	[1]
109	GNDVQHFKVLRDGAG	ubiquitination	[1, 2]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

  

Sequence Annotation

  

Keyword

 Receptor; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0008180; C:signalosome; IEA:Compara.
 GO:0012506; C:vesicle membrane; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:Compara.
 GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:Compara.
 GO:0030838; P:positive regulation of actin filament polymerization; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0043408; P:regulation of MAPK cascade; IEA:Compara. 

Interpro

 IPR000108; p67phox.
 IPR000980; SH2.
 IPR001452; SH3_domain. 

Pfam

 PF00017; SH2
 PF00018; SH3_1 

SMART

 SM00252; SH2
 SM00326; SH3 

PROSITE

 PS50001; SH2
 PS50002; SH3 

PRINTS

 PR00499; P67PHOX.
 PR00401; SH2DOMAIN.
 PR00452; SH3DOMAIN.