UniProt Accession

 CETN1_HUMAN; Q12798; B2R536 

Genbank Protein ID

 U03270; AK312047; CH471113; BC029515 

Genbank Nucleotide ID

 AAC27343.1; BAG34983.1; EAX01727.1; AAH29515.1 

Protein Name

 Centrin-1 

Protein Synonyms/Alias

 Caltractin isoform 2 

Gene Name

 CETN1 

Gene Synonyms/Alias

 CEN1; CETN 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
120	FDDDETGKISFKNLK	ubiquitination	[1]
124	ETGKISFKNLKRVAN	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Plays a fundamental role in microtubule-organizing center structure and function. 

Sequence Annotation

 DOMAIN 28 63 EF-hand 1.
 DOMAIN 64 99 EF-hand 2.
 DOMAIN 101 136 EF-hand 3.
 DOMAIN 137 172 EF-hand 4.  

Keyword

 Calcium; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Metal-binding; Mitosis; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 172 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0032391; C:photoreceptor connecting cilium; IEA:Compara.
 GO:0000922; C:spindle pole; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0034605; P:cellular response to heat; IEA:Compara.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR000629; RNA-helicase_DEAD-box_CS. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS