CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040202
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 GTP:AMP phosphotransferase AK4, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Ak4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
93AARLRRYKDAAKPVIacetylation[1, 2, 3, 4]
93AARLRRYKDAAKPVIsuccinylation[3]
97RRYKDAAKPVIELYKacetylation[1, 2, 3, 4, 5, 6]
97RRYKDAAKPVIELYKsuccinylation[3]
104KPVIELYKSRGVLHQacetylation[1, 2, 3, 4, 5]
104KPVIELYKSRGVLHQsuccinylation[3]
138KITPIQSKEAY****acetylation[3]
138KITPIQSKEAY****succinylation[3]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [6] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 141 AA 
Protein Sequence
XRLMMSELET RSAQHWLLDG FPRTLVQAEA LDGICDVDLV ISLNIPFETL KDRLSRRWIH 60
PSSGRVYNLD FNPPQVQEDD KPEAVAARLR RYKDAAKPVI ELYKSRGVLH QFSGTETNRI 120
WPYVYTLFSN KITPIQSKEA Y 141 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004017; F:adenylate kinase activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro. 
Interpro
 IPR000850; Adenylate_kin.
 IPR007862; Adenylate_kinase_lid-dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00406; ADK
 PF05191; ADK_lid 
SMART
  
PROSITE
 PS00113; ADENYLATE_KINASE 
PRINTS
 PR00094; ADENYLTKNASE.