UniProt Accession

 PCP_MOUSE; Q7TMR0; Q3TLW3; Q3V302; Q8BKK3; Q8R0T8; Q9D049 

Genbank Protein ID

 AK011816; AK051677; AK054462; AK166282; BC026424; BC055022 

Genbank Nucleotide ID

 BAB27858.1; BAC34716.1; BAE20697.1; BAE38679.1; AAH26424.1; AAH55022.1 

Protein Name

 Lysosomal Pro-X carboxypeptidase 

Protein Synonyms/Alias

 Proline carboxypeptidase; Prolylcarboxypeptidase; PRCP 

Gene Name

 Prcp 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
399	CFNQWGVKPRPHWMT	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity). 

Sequence Annotation

 REGION 192 332 SKS domain (By similarity).
 ACT_SITE 177 177 Charge relay system (Potential).
 ACT_SITE 428 428 Charge relay system (Potential).
 ACT_SITE 453 453 Charge relay system (Potential).
 CARBOHYD 99 99 N-linked (GlcNAc...) (Potential).
 CARBOHYD 315 315 N-linked (GlcNAc...) (Potential).
 CARBOHYD 334 334 N-linked (GlcNAc...) (Potential).
 CARBOHYD 343 343 N-linked (GlcNAc...) (Potential).
 CARBOHYD 413 413 N-linked (GlcNAc...) (Potential).
 DISULFID 213 370 By similarity.
 DISULFID 231 308 By similarity.
 DISULFID 262 341 By similarity.
 DISULFID 362 392 By similarity.  

Keyword

 Alternative splicing; Carboxypeptidase; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease; Reference proteome; Signal; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 491 AA 

Protein Sequence

Gene Ontology

 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
 GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR008758; Peptidase_S28. 

Pfam

 PF05577; Peptidase_S28 

SMART

  

PROSITE

  

PRINTS