UniProt Accession

 ROA0_MOUSE; Q9CX86 

Genbank Protein ID

 AK019388; AC165251 

Genbank Nucleotide ID

 BAB31694.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein A0 

Protein Synonyms/Alias

 hnRNP A0 

Gene Name

 Hnrnpa0 

Gene Synonyms/Alias

 Hnrpa0 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
99	GAHAKVKKLFVGGLK	acetylation	[1]
99	GAHAKVKKLFVGGLK	succinylation	[1]
99	GAHAKVKKLFVGGLK	ubiquitination	[2]
133	KAEIIADKQSGKKRG	acetylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post- transcriptional regulation of cytokines mRNAs. 

Sequence Annotation

 DOMAIN 7 86 RRM 1.
 DOMAIN 98 175 RRM 2.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 84 84 Phosphoserine; by MAPKAPK2.
 MOD_RES 293 293 Dimethylated arginine (By similarity).  

Keyword

 Acetylation; Complete proteome; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 305 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0017091; F:AU-rich element binding; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0070935; P:3'-UTR-mediated mRNA stabilization; IDA:UniProtKB.
 GO:0006954; P:inflammatory response; IDA:UniProtKB.
 GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS