CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001033
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UvrABC system protein C 
Protein Synonyms/Alias
 Protein UvrC; Excinuclease ABC subunit C 
Gene Name
 uvrC 
Gene Synonyms/Alias
 STM1946 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
41GKAKDLKKRLSSYFRacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity). 
Sequence Annotation
 DOMAIN 16 94 GIY-YIG.
 DOMAIN 204 239 UVR.  
Keyword
 Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease; Reference proteome; SOS response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 610 AA 
Protein Sequence
MSEIFDAKAF LKTVTSQPGV YRMYDAGGTV IYVGKAKDLK KRLSSYFRSN LASRKTEALV 60
AQIQHIDVTV THTETEALLL EHNYIKLYQP RYNVLLRDDK SYPFIFLSGD THPRLAMHRG 120
AKHAKGEYFG PFPNGYAVRE TLALLQKIFP IRQCENSVYR NRSRPCLQYQ IGRCLGPCVA 180
GLVSEEEYAQ QVEYVRLFLS GKDDQVLTQL IARMEKASQD LAFEEAARIR DQIQAVRRVT 240
EKQFVSNAGD DLDVIGVAFD AGMACVHVLF IRQGKVLGSR SYFPKVPGGT ELGEVVETFV 300
GQFYLQGSQM RTLPGEILLD FNLSDKTLLA DSLSELAGRR IHVQTKPRGD RARYLKLART 360
NAATALITKL SQQSTITQRL SALAAVLKLP AIKRMECFDI SHTMGEQTVA SCVVFDANGP 420
LRAEYRRYNI AGITPGDDYA AMNQVLRRRY GKAIEESKIP DVILIDGGKG QLAQAKAVFA 480
ELDVPWDKHR PLLLGVAKGA DRKAGLETLF FEPEGEGFSL PPDSPALHVI QHIRDESHDH 540
AIGGHRKKRA KVKNTSTLET IEGVGPKRRQ MLLKYMGGLQ GLRNASVEEI AKVPGISQGL 600
AEKIFWSLKH 610 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0009380; C:excinuclease repair complex; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:HAMAP.
 GO:0009381; F:excinuclease ABC activity; IEA:HAMAP.
 GO:0006289; P:nucleotide-excision repair; IEA:HAMAP.
 GO:0009432; P:SOS response; IEA:HAMAP. 
Interpro
 IPR027299; GIY-YIG_dom.
 IPR000305; GIY-YIG_SF.
 IPR000445; HhH_motif.
 IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
 IPR010994; RuvA_2-like.
 IPR001943; UVR_dom.
 IPR004791; UvrC.
 IPR001162; UvrC_homol_region. 
Pfam
 PF01541; GIY-YIG
 PF00633; HHH
 PF02151; UVR
 PF08459; UvrC_HhH_N 
SMART
 SM00465; GIYc
 SM00278; HhH1 
PROSITE
 PS50164; GIY_YIG
 PS50151; UVR
 PS50165; UVRC 
PRINTS