CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007721
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homeobox protein Nkx-2.1 
Protein Synonyms/Alias
 Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1 
Gene Name
 NKX2-1 
Gene Synonyms/Alias
 NKX2A; TITF1; TTF1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
184ERRFKQQKYLSAPERacetylation[1]
Reference
 [1] Mutation of a lysine residue in a homeodomain generates dominant negative thyroid transcription factor 1.
 Yang L, Yan D, Bruggeman M, Du H, Yan C.
 Biochemistry. 2004 Oct 5;43(39):12489-97. [PMID: 15449938] 
Functional Description
 Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. 
Sequence Annotation
 DNA_BIND 161 220 Homeobox.  
Keyword
 Activator; Alternative splicing; Complete proteome; Disease mutation; DNA-binding; Homeobox; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 371 AA 
Protein Sequence
MSMSPKHTTP FSVSDILSPL EESYKKVGME GGGLGAPLAA YRQGQAAPPT AAMQQHAVGH 60
HGAVTAAYHM TAAGVPQLSH SAVGGYCNGN LGNMSELPPY QDTMRNSASG PGWYGANPDP 120
RFPAISRFMG PASGMNMSGM GGLGSLGDVS KNMAPLPSAP RRKRRVLFSQ AQVYELERRF 180
KQQKYLSAPE REHLASMIHL TPTQVKIWFQ NHRYKMKRQA KDKAAQQQLQ QDSGGGGGGG 240
GTGCPQQQQA QQQSPRRVAV PVLVKDGKPC QAGAPAPGAA SLQGHAQQQA QHQAQAAQAA 300
AAAISVGSGG AGLGAHPGHQ PGSAGQSPDL AHHAASPAAL QGQVSSLSHL NSSGSDYGTM 360
SCSTLLYGRT W 371 
Gene Ontology
 GO:0005654; C:nucleoplasm; ISS:UniProtKB.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:Compara.
 GO:0007411; P:axon guidance; IEA:Compara.
 GO:0021795; P:cerebral cortex cell migration; IEA:Compara.
 GO:0021892; P:cerebral cortex GABAergic interneuron differentiation; IEA:Compara.
 GO:0060486; P:Clara cell differentiation; IEA:Compara.
 GO:0031128; P:developmental induction; IEA:Compara.
 GO:0007492; P:endoderm development; IEA:Compara.
 GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEP:UniProtKB.
 GO:0021798; P:forebrain dorsal/ventral pattern formation; IEA:Compara.
 GO:0021877; P:forebrain neuron fate commitment; IEA:Compara.
 GO:0021759; P:globus pallidus development; IMP:UniProtKB.
 GO:0021766; P:hippocampus development; IEA:Compara.
 GO:0033327; P:Leydig cell differentiation; IEA:Compara.
 GO:0007626; P:locomotory behavior; IEA:Compara.
 GO:0060430; P:lung saccule development; IEA:Compara.
 GO:0042696; P:menarche; IEA:Compara.
 GO:0030336; P:negative regulation of cell migration; IDA:UniProtKB.
 GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0048709; P:oligodendrocyte differentiation; IEA:Compara.
 GO:0006644; P:phospholipid metabolic process; IEA:Compara.
 GO:0021983; P:pituitary gland development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0009725; P:response to hormone stimulus; IEP:UniProtKB.
 GO:0030878; P:thyroid gland development; IMP:UniProtKB.
 GO:0060510; P:Type II pneumocyte differentiation; IEA:Compara. 
Interpro
 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 
Pfam
 PF00046; Homeobox 
SMART
 SM00389; HOX 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 
PRINTS
 PR00024; HOMEOBOX.