UniProt Accession

 MDH_BACSU; P49814 

Genbank Protein ID

 U05257; AF008220; AL009126 

Genbank Nucleotide ID

 AAA96343.1; AAC00347.1; CAB14872.1 

Protein Name

 Malate dehydrogenase 

Protein Synonyms/Alias

 Vegetative protein 69; VEG69 

Gene Name

 mdh 

Gene Synonyms/Alias

 citH; BSU29120 

Created Date

 July 27, 2013 

Organism

 Bacillus subtilis (strain 168) 

NCBI Taxa ID

 224308 

Lysine Modification

Position	Peptide	Type	References
102	DLVSTNEKIMRSVTQ	acetylation	[1]
136	AMTYAVYKESGFPKE	acetylation	[1]
204	PLETLIPKERIDAIV	acetylation	[1]
299	YERAQLNKSVESVKN	acetylation	[1]

Reference

 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 

Functional Description

 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity). 

Sequence Annotation

 NP_BIND 12 17 NAD (By similarity).
 NP_BIND 123 125 NAD (By similarity).
 ACT_SITE 180 180 Proton acceptor (By similarity).
 BINDING 36 36 NAD (By similarity).
 BINDING 87 87 Substrate (By similarity).
 BINDING 93 93 Substrate (By similarity).
 BINDING 100 100 NAD (By similarity).
 BINDING 125 125 Substrate (By similarity).
 BINDING 156 156 Substrate (By similarity).
 MOD_RES 149 149 Phosphoserine.  

Keyword

 Complete proteome; Direct protein sequencing; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 312 AA 

Protein Sequence

Gene Ontology

 GO:0030060; F:L-malate dehydrogenase activity; IEA:HAMAP.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006108; P:malate metabolic process; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP. 

Interpro

 IPR001557; L-lactate/malate_DH.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR011275; Malate_DH_type3.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 

SMART

  

PROSITE

  

PRINTS

 PR00086; LLDHDRGNASE.