UniProt Accession

 PDIA2_MOUSE; D3Z6P0; Q14AV9 

Genbank Protein ID

 AC126438; BC116671 

Genbank Nucleotide ID

 AAI16672.1 

Protein Name

 Protein disulfide-isomerase A2 

Protein Synonyms/Alias

 PDIp 

Gene Name

 Pdia2 

Gene Synonyms/Alias

 Pdip 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
113	PAEPELTKEFEVVGY	ubiquitination	[1]
229	DTVVLFKKFDEGRAD	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity). 

Sequence Annotation

 DOMAIN 29 155 Thioredoxin 1.
 DOMAIN 355 499 Thioredoxin 2.
 MOTIF 524 527 Prevents secretion from ER (Potential).
 ACT_SITE 74 74 Nucleophile (By similarity).
 ACT_SITE 77 77 Nucleophile (By similarity).
 ACT_SITE 421 421 Nucleophile (By similarity).
 ACT_SITE 424 424 Nucleophile (By similarity).
 CARBOHYD 130 130 N-linked (GlcNAc...) (Potential).
 CARBOHYD 287 287 N-linked (GlcNAc...) (Potential).
 CARBOHYD 518 518 N-linked (GlcNAc...) (Potential).
 DISULFID 74 77 Redox-active (By similarity).
 DISULFID 421 424 Redox-active (By similarity).  

Keyword

 Alternative splicing; Chaperone; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Isomerase; Lipid-binding; Redox-active center; Reference proteome; Repeat; Signal; Steroid-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 527 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0003756; F:protein disulfide isomerase activity; TAS:MGI.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
 GO:0001666; P:response to hypoxia; IEA:Compara. 

Interpro

 IPR005792; Prot_disulphide_isomerase.
 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS00014; ER_TARGET
 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS

 PR00421; THIOREDOXIN.