CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028327
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription termination factor Rho 
Protein Synonyms/Alias
 ATP-dependent helicase Rho 
Gene Name
 rho 
Gene Synonyms/Alias
 MSMEG_4954 
Created Date
 July 27, 2013 
Organism
 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
NCBI Taxa ID
 246196 
Lysine Modification
Position
Peptide
Type
References
320VSMNMVRKNGLRRGDpupylation[1]
Reference
 [1] Proteome-wide identification of mycobacterial pupylation targets.
 Poulsen C, Akhter Y, Jeon AH, Schmitt-Ulms G, Meyer HE, Stefanski A, Stühler K, Wilmanns M, Song YH.
 Mol Syst Biol. 2010 Jul 13;6:386. [PMID: 20631680] 
Functional Description
 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity). 
Sequence Annotation
 NP_BIND 406 411 ATP (By similarity).
 NP_BIND 418 423 ATP (By similarity).
 BINDING 449 449 ATP (By similarity).  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome; RNA-binding; Transcription; Transcription regulation; Transcription termination. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 664 AA 
Protein Sequence
MTETDLFTAD NASDTGDLSG AVKSNTAPRA RSASLSTMVL PELRALAKEI GVEGASGLRK 60
SELIAAIRAH RGESNGRTAE ASSPATADAQ TGEQAAEAPA PRRRERRAST RQAGAPVAEK 120
GEAGEKAGEK TEAQPEAKTE AQPEAKAEAP AEAKTERAEK ADKPAKEAQT KAAEAPEAGE 180
SQESQPRQRR ERSGRQDRAD RGEKDGQDGK QDQGKQDRSE RDQDQQGGGQ QNRGGGSGNN 240
ADSDDDGEGR QGRRGRRFRD RRRRGERGGE GGNDTELRED DVVQPVAGIL DVLDNYAFVR 300
TSGYLAGPND VYVSMNMVRK NGLRRGDAVT GAVRVPREGD SGGQNQRQKF NPLVRLDTVN 360
GGSVEDAKKR PEFGKLTPLY PNERLRLETS PERLSTRVID LIMPIGKGQR ALIVSPPKAG 420
KTTILQDIAN AITRNNPECH LMVVLVDERP EEVTDMQRSV KGEVIASTFD RPPSDHTQAA 480
ELAIERAKRL VEQGKDVVVL LDSITRLGRA YNNASPASGR ILSGGVDSTA LYPPKRFLGA 540
ARNIEHGGSL TIIATAMVET GSTGDTVIFE EFKGTGNAEL KLDRKIAERR VFPAVDVNPS 600
GTRKDELLLS PDEFAIVHKL RRVLSGLDSH QAIDLLISQL RKTKTNYEFL VQVSKTAPGS 660
MDVD 664 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004386; F:helicase activity; IEA:HAMAP.
 GO:0003723; F:RNA binding; IEA:HAMAP.
 GO:0008186; F:RNA-dependent ATPase activity; IEA:InterPro.
 GO:0006353; P:DNA-dependent transcription, termination; IEA:HAMAP.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
 IPR011129; Cold_shock_prot.
 IPR012340; NA-bd_OB-fold.
 IPR027417; P-loop_NTPase.
 IPR011112; Rho_N.
 IPR011113; Rho_RNA-bd.
 IPR004665; Term_rho. 
Pfam
 PF00006; ATP-synt_ab
 PF07498; Rho_N
 PF07497; Rho_RNA_bind 
SMART
 SM00382; AAA
 SM00357; CSP
 SM00959; Rho_N 
PROSITE
  
PRINTS