UniProt Accession

 MTA70_HUMAN; Q86U44; O14736; Q86V05; Q9HB32 

Genbank Protein ID

 AF014837; AF283991; AE000658; BX247964; BC003031; BC001650; BC052244 

Genbank Nucleotide ID

 AAB71850.1; AAG13956.1; CAD62303.1; AAH03031.1; AAH01650.1; AAH52244.1 

Protein Name

 N6-adenosine-methyltransferase 70 kDa subunit 

Protein Synonyms/Alias

 MT-A70; Methyltransferase-like protein 3 

Gene Name

 METTL3 

Gene Synonyms/Alias

 MTA70 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
256	LLNTTTAKEQSIVEK	ubiquitination	[1]
305	HFRRIINKHTDESLG	ubiquitination	[1]
459	VDEIIWVKTNQLQRI	ubiquitination	[1, 2, 3]
480	GHWLNHGKEHCLVGV	ubiquitination	[1]
488	EHCLVGVKGNPQGFN	ubiquitination	[1, 3]
513	EVRSTSHKPDEIYGM	ubiquitination	[1]
576	YPDGIISKPKNL***	ubiquitination	[1]
578	DGIISKPKNL*****	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 43 43 Phosphoserine.
 MOD_RES 219 219 Phosphoserine.
 MOD_RES 243 243 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Methyltransferase; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 580 AA 

Protein Sequence

Gene Ontology

 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0016422; F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; IMP:UniProtKB.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0010467; P:gene expression; TAS:Reactome. 

Interpro

 IPR025848; MT-A70.
 IPR007757; MT-A70-like. 

Pfam

 PF05063; MT-A70 

SMART

  

PROSITE

 PS51143; MT_A70 

PRINTS