CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013275
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PX domain-containing protein kinase-like protein 
Protein Synonyms/Alias
 Modulator of Na,K-ATPase; MONaKA 
Gene Name
 Pxk 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
249KPKDPFLKKYCNPKKacetylation[1]
414PQFKIPTKLREALRIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity (By similarity). 
Sequence Annotation
 DOMAIN 14 126 PX.
 DOMAIN 88 481 Protein kinase.
 DOMAIN 549 568 WH2.  
Keyword
 Actin-binding; Cell membrane; Complete proteome; Cytoplasm; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 580 AA 
Protein Sequence
MAFMEKPPAR KVLLDDTVPL TAAVEASQSL QSHTEYIIRV QRGISAENSW QIVRRYSDFD 60
LLNNSLQITG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL NVIMANHVLS NCELLKKFLD 120
PNNYSANYTE IALQQVSMFF RSEPKWEVVE PLKDIGWRIR KKYFLMKIKN QPKERLVLSW 180
ADLGPDKYLS DKDFQCLIKL LPSCVHPYIY RVTFATASES SALLIRTFND KGTLKDLIYK 240
AKPKDPFLKK YCNPKKTQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH AANVMLDGNT 300
CRLLDLENSL LGLPSFYRSY FTQFRKINTL ESVDVHCFGH LLYEMTYGRP PDSVPVDSFP 360
PASSMAVVAV LESTLSCEAC KNGMPTVSRL LQMPLFSDVL LTTSEKPQFK IPTKLREALR 420
IAKECIEKRL TEEQKQIHQH RRLTRAQSHH GSEEERKRRK ILARKKSKRS AVENSEEQPV 480
KHSNANNSAG SGASSPLTSP SSPTPPSTAG LSSALPPPPP PPPPPPPPAG PSPGTEMPAP 540
PLPQAVNGVN RGALLSSIQN FQKGTLRKAK TCDHSAPKIG 580 
Gene Ontology
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0032780; P:negative regulation of ATPase activity; IEA:Compara.
 GO:0043271; P:negative regulation of ion transport; IEA:Compara.
 GO:0050804; P:regulation of synaptic transmission; ISS:UniProtKB. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR001683; Phox.
 IPR000719; Prot_kinase_cat_dom.
 IPR003124; WH2_dom. 
Pfam
 PF00069; Pkinase
 PF00787; PX
 PF02205; WH2 
SMART
 SM00312; PX 
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS50195; PX
 PS51082; WH2 
PRINTS