UniProt Accession

 SRPB_YEAST; P36057; D6VX44 

Genbank Protein ID

 Z26877; Z28154; BK006944 

Genbank Nucleotide ID

 CAA81499.1; CAA81995.1; DAA09010.1 

Protein Name

 Signal recognition particle receptor subunit beta 

Protein Synonyms/Alias

 SR-beta 

Gene Name

 SRP102 

Gene Synonyms/Alias

 YKL154W; YKL609 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
177	ALESEIQKVIERRKK	acetylation	[1]
192	SLNEVERKINEEDYA	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR. 

Sequence Annotation

 NP_BIND 45 53 GTP.
 NP_BIND 66 69 GTP.
 NP_BIND 154 157 GTP.
 BINDING 90 90 GTP; via amide nitrogen.  

Keyword

 3D-structure; Complete proteome; Endoplasmic reticulum; GTP-binding; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:SGD.
 GO:0005785; C:signal recognition particle receptor complex; TAS:SGD.
 GO:0005525; F:GTP binding; IPI:SGD.
 GO:0003924; F:GTPase activity; ISS:SGD.
 GO:0005047; F:signal recognition particle binding; IPI:SGD.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:SGD. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR019009; SRP_receptor_beta_su. 

Pfam

 PF09439; SRPRB 

SMART

  

PROSITE

  

PRINTS