UniProt Accession

 H2B_ONCMY; P69069; P02282 

Genbank Protein ID

 X02916 

Genbank Nucleotide ID

 CAA26673.1 

Protein Name

 Histone H2B 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 

NCBI Taxa ID

 8022 

Lysine Modification

Position	Peptide	Type	References
6	**MPEPAKSAPKKGS	acetylation	[1, 2]
11	PAKSAPKKGSKKAVT	acetylation	[1, 2]
14	SAPKKGSKKAVTKTA	acetylation	[1, 2]
19	GSKKAVTKTAGKGGK	acetylation	[1, 2]

Reference

 [1] Multiacetylated forms of H4 are found in a putative transcriptionally competent chromatin fraction from trout testis.
 Levy-Wilson B, Watson DC, Dixon GH.
 Nucleic Acids Res. 1979 Jan;6(1):259-74. [PMID: 424292]
 [2] Amino-terminal sequences and sites of in vivo acetylation of trout-testis histones 3 and IIb 2 .
 Candido EP, Dixon GH.
 Proc Natl Acad Sci U S A. 1972 Aug;69(8):2015-9. [PMID: 4506069] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 6 6 N6-acetyllysine.
 MOD_RES 11 11 N6-acetyllysine.
 MOD_RES 13 13 Phosphoserine (By similarity).
 MOD_RES 14 14 N6-acetyllysine.
 MOD_RES 19 19 N6-acetyllysine.
 CARBOHYD 111 111 O-linked (GlcNAc...) (By similarity).
 CROSSLNK 119 119 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Chromosome; Direct protein sequencing; DNA-binding; Glycoprotein; Isopeptide bond; Nucleosome core; Nucleus; Phosphoprotein; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 124 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000558; Histone_H2B. 

Pfam

 PF00125; Histone 

SMART

 SM00427; H2B 

PROSITE

 PS00357; HISTONE_H2B 

PRINTS

 PR00621; HISTONEH2B.