UniProt Accession

 RL12A_YEAST; P0CX53; D3DLJ6; P05741; P17079 

Genbank Protein ID

 X51519; U18795; AY693201; BK006939 

Genbank Nucleotide ID

 CAA35891.1; AAB65033.1; AAT93220.1; DAA07600.1 

Protein Name

 60S ribosomal protein L12-A 

Protein Synonyms/Alias

 L15; YL23 

Gene Name

 RPL12A 

Gene Synonyms/Alias

 RPL15B; YEL054C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
4	****MPPKFDPNEVK	methylation	[1, 2]
11	KFDPNEVKYLYLRAV	methylation	[1]
31	ASAALAPKIGPLGLS	acetylation	[3]
31	ASAALAPKIGPLGLS	ubiquitination	[4]
40	GPLGLSPKKVGEDIA	ubiquitination	[4]
41	PLGLSPKKVGEDIAK	ubiquitination	[4]
48	KVGEDIAKATKEFKG	acetylation	[3]
48	KVGEDIAKATKEFKG	ubiquitination	[4]
86	SLVITALKEPPRDRK	acetylation	[3]
99	RKKDKNVKHSGNIQL	ubiquitination	[4]
130	RTLASVTKEILGTAQ	ubiquitination	[4]
146	VGCRVDFKNPHDIIE	acetylation	[3]
146	VGCRVDFKNPHDIIE	ubiquitination	[4]

Reference

 [1] A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10.
 Porras-Yakushi TR, Whitelegge JP, Clarke S.
 J Biol Chem. 2006 Nov 24;281(47):35835-45. [PMID: 17005568]
 [2] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681]
 [3] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [4] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 This protein binds directly to 26S ribosomal RNA. 

Sequence Annotation

 MOD_RES 2 2 N,N-dimethylproline; by NTM1.
 MOD_RES 4 4 N6,N6,N6-trimethyllysine; by RKM2.
 MOD_RES 11 11 N6,N6,N6-trimethyllysine; by RKM2.
 MOD_RES 25 25 Phosphoserine.
 MOD_RES 38 38 Phosphoserine.
 MOD_RES 67 67 N5-methylarginine; by RMT2.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Methylation; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 165 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; TAS:SGD.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; TAS:SGD.
 GO:0002181; P:cytoplasmic translation; TAS:SGD.
 GO:0000027; P:ribosomal large subunit assembly; IMP:SGD. 

Interpro

 IPR000911; Ribosomal_L11.
 IPR020783; Ribosomal_L11_C.
 IPR020785; Ribosomal_L11_CS.
 IPR020784; Ribosomal_L11_N. 

Pfam

 PF00298; Ribosomal_L11
 PF03946; Ribosomal_L11_N 

SMART

 SM00649; RL11 

PROSITE

 PS00359; RIBOSOMAL_L11 

PRINTS