| Tag | Content |
|---|
| CPLM ID | CPLM-018206 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Wiskott-Aldrich syndrome protein family member 3 |
Protein Synonyms/Alias | WASP family protein member 3; Protein WAVE-3 |
Gene Name | Wasf3 |
Gene Synonyms/Alias | Wave3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 162 | SYFFDLWKEKMLQDT | ubiquitination | [1] | | 465 | EQREQEAKREPVGND | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). |
Sequence Annotation | DOMAIN 439 456 WH2.
MOD_RES 151 151 Phosphotyrosine; by ABL1 (By similarity).
MOD_RES 248 248 Phosphotyrosine; by ABL1 (By similarity).
MOD_RES 337 337 Phosphotyrosine; by ABL1 (By similarity).
MOD_RES 485 485 Phosphotyrosine; by ABL1 (By similarity). |
Keyword | Actin-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 501 AA |
Protein Sequence | MPLVKRNIEP RHLCRGALPE GVTSELECVT NSTLAAIIRQ LSSLSKHAED IFGELFNEAN 60
NFYIRANSLQ DRIDRLAVKV TQLDSTVEEV SLQDINMKKA FKSSTIQDQQ VVSKNSIPNP 120
VADIYNQSDK PPPLSILTPY RDDKKDGLKF YTDPSYFFDL WKEKMLQDTE DKRKEKRRQK 180
EQKRVDGTTR EVKKVRKARN RRQEWNMMAY DKELRPDNRL SQSVHHGASS EGSLSPDTRS 240
HTSDVTDYSY PATPNHALQA QPATPSYTAG DAPLHGTTNQ GAEHEYRPSS ASARHMALNR 300
PQQPPPPPPP QAPEGSQAST SVAPADYGML PAQIIEYYSP SGPPPPPPPP MIPSAQTAFV 360
SPLQMPTQPP FPASAVSTYP TPPHQPSTGL LATAPPPPGP PPPPPGPPGP SSLSSSPMHG 420
PPVAEAKRPE PAQPPISDAR SDLLAAIRMG IQLKKVQEQR EQEAKREPVG NDVATILSRR 480
IAVEYSDSDD DSEFDENDWS D 501 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0030027; C:lamellipodium; IDA:MGI. GO:0007010; P:cytoskeleton organization; ISS:UniProtKB. GO:0030032; P:lamellipodium assembly; IMP:MGI. GO:0014003; P:oligodendrocyte development; IMP:MGI. GO:0031643; P:positive regulation of myelination; IDA:MGI. GO:0008360; P:regulation of cell shape; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |