CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037415
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Vacuolar protein sorting-associated protein 41 homolog 
Protein Synonyms/Alias
  
Gene Name
 VPS41 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
333PRDVVVAKERDQDDHubiquitination[1]
528HNLFSSIKDKIVLLMubiquitination[1, 2]
617STHCPLEKALEICQQubiquitination[1]
646GNSRSALKMIMEELHubiquitination[1, 2]
706ILLIHRIKEGMEIPNubiquitination[1]
737LLREGCKKILVADSLubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 829 AA 
Protein Sequence
MAEAEEQETG SLEESTDESE EEESEEEPKL KYERLSNGVT EILQKDAASC MTVHDKFLAL 60
GTHYGKVYLL DVQGNITQKF DVVQVFGLYS GEEFHETFDC PIKIIAVHPH FVRSSCKQFV 120
TGGKKLLLFE RSWMNRWKSA VLHEGEGNIR SVKWRGHLIA WANNMGVKIF DIISKQRITN 180
VPRDDISLRP DMYPCSLCWK DNVTLIIGWG TSVKVCSVKE RHASEMRDLP SRYVEIVSQF 240
ETEFYISGLA PLCDQLVVLS YVKEISEKTE REYCARPRLD IIQPLSETCE EISSDALTVR 300
GFQENECRDY HLEYSEGESL FYIVSPRDVV VAKERDQDDH IDWLLEKKKY EEALMAAEIS 360
QKNIKRHKIL DIGLAYINHL VERGDYDIAA RKCQKILGKN AALWEYEVYK FKEIGQLKAI 420
SPYLPRGDPV LKPLIYEMIL HEFLESDYEG FATLIREWPG DLYNNSVIVQ AVRDHLKKDS 480
QNKTLLKTLA ELYTYDKNYG NALEIYLTLR HKDVFQLIHK HNLFSSIKDK IVLLMDFDSE 540
KAVDMLLDNE DKISIKKVVE ELEDRPELQH VYLHKLFKRD HHKGQRYHEK QISLYAEYDR 600
PNLLPFLRDS THCPLEKALE ICQQRNFVEE TVYLLSRMGN SRSALKMIME ELHDVDKAIE 660
FAKEQDDGEL WEDLILYSID KPPFITGLLN NIGTHVDPIL LIHRIKEGME IPNLRDSLVK 720
ILQDYNLQIL LREGCKKILV ADSLSLLKKM HRTQMKGVLV DEENICESCL SPILPSDAAK 780
PFSVVVFHCR HMFHKECLPM PSMNSAAQFC NICSAKNRGP GSAILEMKK 829 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR000547; Clathrin_H-chain/VPS_repeat.
 IPR011990; TPR-like_helical.
 IPR016902; VPS41.
 IPR017986; WD40_repeat_dom.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00637; Clathrin 
SMART
 SM00299; CLH
 SM00184; RING 
PROSITE
 PS50089; ZF_RING_2 
PRINTS