| Tag | Content |
|---|
| CPLM ID | CPLM-015853 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tubulin polymerization-promoting protein |
Protein Synonyms/Alias | TPPP |
Gene Name | Tppp |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 124 | EALEELAKKRFKDKS | ubiquitination | [1] | | 155 | PVISGVTKAVSSPTV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. |
Sequence Annotation | REGION 1 115 Mediates interaction with LIMK1 (By
MOD_RES 15 15 Phosphothreonine.
MOD_RES 19 19 Phosphoserine (By similarity).
MOD_RES 31 31 Phosphoserine.
MOD_RES 34 34 Phosphoserine (By similarity).
MOD_RES 91 91 Phosphothreonine (By similarity).
MOD_RES 158 158 Phosphoserine (By similarity).
MOD_RES 159 159 Phosphoserine (By similarity).
CARBOHYD 151 151 O-linked (GlcNAc). |
Keyword | Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Glycoprotein; Microtubule; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 218 AA |
Protein Sequence | MADSKAKPAK AANKTPPKSP GDPARAAKRL SLESEGANEG ATAAPELSAL EEAFRRFAVH 60
GDTRATGKEM HGKNWSKLCK DCHVIDGKNV TVTDVDIVFS KIKGKSCRTI TFEQFQEALE 120
ELAKKRFKDK SSEEAVREVH RLIEGRAPVI SGVTKAVSSP TVSRLTDTSK FTGSHKERFD 180
QSGKGKGKAG RVDLVDESGY VPGYKHAGTY DQKVQGGK 218 |
Gene Ontology | GO:0005925; C:focal adhesion; IEA:Compara. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IDA:UniProtKB. GO:0048471; C:perinuclear region of cytoplasm; ISS:HGNC. GO:0005886; C:plasma membrane; IEA:Compara. GO:0008017; F:microtubule binding; ISS:HGNC. GO:0001578; P:microtubule bundle formation; ISS:HGNC. GO:0046785; P:microtubule polymerization; IDA:UniProtKB. GO:0032273; P:positive regulation of protein polymerization; ISS:HGNC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |