| Tag | Content |
|---|
| CPLM ID | CPLM-024203 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin-like modifier-activating enzyme 6 |
Protein Synonyms/Alias | Ubiquitin-activating enzyme 6; Monocyte protein 4; MOP-4; Ubiquitin-activating enzyme E1-like protein 2; E1-L2 |
Gene Name | UBA6 |
Gene Synonyms/Alias | MOP4; UBE1L2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 265 | SLFWQSPKRPPSPIK | ubiquitination | [1] | | 415 | KTKRIAGKIIPAIAT | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. |
Sequence Annotation | NP_BIND 470 500 ATP (By similarity).
ACT_SITE 625 625 Glycyl thioester intermediate (By
MOD_RES 1 1 N-acetylmethionine.
MOD_RES 544 544 N6-acetyllysine. |
Keyword | Acetylation; Alternative splicing; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Polymorphism; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1052 AA |
Protein Sequence | MLKNFALLGV GTSKEKGMIT VTDPDLIEKS NLNRQFLFRP HHIQKPKSYT AADATLKINS 60
QIKIDAHLNK VCPTTETIYN DEFYTKQDVI ITALDNVEAR RYVDSRCLAN LRPLLDSGTM 120
GTKGHTEVIV PHLTESYNSH RDPPEEEIPF CTLKSFPAAI EHTIQWARDK FESSFSHKPS 180
LFNKFWQTYS SAEEVLQKIQ SGHSLEGCFQ VIKLLSRRPR NWSQCVELAR LKFEKYFNHK 240
ALQLLHCFPL DIRLKDGSLF WQSPKRPPSP IKFDLNEPLH LSFLQNAAKL YATVYCIPFA 300
EEDLSADALL NILSEVKIQE FKPSNKVVQT DETARKPDHV PISSEDERNA IFQLEKAILS 360
NEATKSDLQM AVLSFEKDDD HNGHIDFITA ASNLRAKMYS IEPADRFKTK RIAGKIIPAI 420
ATTTATVSGL VALEMIKVTG GYPFEAYKNC FLNLAIPIVV FTETTEVRKT KIRNGISFTI 480
WDRWTVHGKE DFTLLDFINA VKEKYGIEPT MVVQGVKMLY VPVMPGHAKR LKLTMHKLVK 540
PTTEKKYVDL TVSFAPDIDG DEDLPGPPVR YYFSHDTD 578 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:LIFEdb. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0019780; F:FAT10 activating enzyme activity; IMP:UniProtKB. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0016567; P:protein ubiquitination; IMP:UniProtKB. GO:0006511; P:ubiquitin-dependent protein catabolic process; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |