CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038490
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine protease hepsin 
Protein Synonyms/Alias
  
Gene Name
 Hpn 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
33CSRPQPGKGGRTAACubiquitination[1]
96SRLAVFDKTEGTWRLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Hydrolase; Protease; Reference proteome; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 445 AA 
Protein Sequence
MWVGARDDAG HMADEEPGAH RGGSTCSRPQ PGKGGRTAAC CSRPKVAALI VGTLLFLTGI 60
GAASWAIVTI LLQSDQEPLY QVQLSPGDSR LAVFDKTEGT WRLLCSSRSN ARVAGLGCEE 120
MGFLRALAHS ELDVRTAGAN GTSGFFCVDE GGLPLAQRLL DVISVCDCPR GRFLTATCQD 180
CGRRKLPVDR IVGGQDSSLG RWPWQVSLRY DGTHLCGGSL LSGDWVLTAA HCFPERNRVL 240
SRWRVFAGAV ARTSPHAVQL GVQAVIYHGG YLPFRDPTID ENSNDIALVH LSSSLPLTEY 300
IQPVCLPAAG QALVDGKVCT VTGWGNTQFY GQQAMVLQEA RVPIISNEVC NSPDFYGNQI 360
KPKMFCAGYP EGGIDACQGD SGGPFVCEDS ISGTSRWRLC GIVSWGTGCA LARKPGVYTK 420
VTDFREWIFK AIKTHSEASG MVTQP 445 
Gene Ontology
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005044; F:scavenger receptor activity; IEA:InterPro.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0070008; F:serine-type exopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR015352; Hepsin-SRCR.
 IPR001254; Peptidase_S1.
 IPR018114; Peptidase_S1_AS.
 IPR001314; Peptidase_S1A.
 IPR017448; Srcr_rcpt-rel.
 IPR009003; Trypsin-like_Pept_dom. 
Pfam
 PF09272; Hepsin-SRCR
 PF00089; Trypsin 
SMART
 SM00202; SR
 SM00020; Tryp_SPc 
PROSITE
 PS50240; TRYPSIN_DOM
 PS00134; TRYPSIN_HIS
 PS00135; TRYPSIN_SER 
PRINTS
 PR00722; CHYMOTRYPSIN.