CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010503
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 28S ribosomal protein S22, mitochondrial 
Protein Synonyms/Alias
 MRP-S22; S22mt 
Gene Name
 MRPS22 
Gene Synonyms/Alias
 C3orf5; RPMS22; GK002 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
66ESGSPETKKPTFMDEubiquitination[1]
67SGSPETKKPTFMDEEubiquitination[1]
99KPAIQELKPPTYKLMubiquitination[1]
104ELKPPTYKLMTQAQLubiquitination[2, 3]
127EAAKVRLKMPPVLEEubiquitination[1, 4, 5]
146NDVLAEDKILEGTETubiquitination[1, 4]
155LEGTETTKYVFTDISubiquitination[1]
199MIQVYFPKEGRKILTubiquitination[1, 2, 3, 4, 5]
211ILTPIIFKEENLRTMacetylation[6]
211ILTPIIFKEENLRTMubiquitination[1, 4]
255KTYEDIDKRGKYDLLacetylation[6]
255KTYEDIDKRGKYDLLubiquitination[5]
258EDIDKRGKYDLLRSTacetylation[6]
280WYFVNNKKIDGLLIDubiquitination[5]
318GQSAQGAKDQAAEGIubiquitination[4]
329AEGINLIKVFAKTEAubiquitination[1, 2, 3, 4, 5]
333NLIKVFAKTEAQKGAubiquitination[5]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861
Functional Description
  
Sequence Annotation
 MOD_RES 211 211 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Disease mutation; Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 360 AA 
Protein Sequence
MAPLGTTVLL WSLLRSSPGV ERVCFRARIQ PWHGGLLQPL PCSFEMGLPR RRFSSEAAES 60
GSPETKKPTF MDEEVQSILT KMTGLNLQKT FKPAIQELKP PTYKLMTQAQ LEEATRQAVE 120
AAKVRLKMPP VLEERVPIND VLAEDKILEG TETTKYVFTD ISYSIPHRER FIVVREPSGT 180
LRKASWEERD RMIQVYFPKE GRKILTPIIF KEENLRTMYS QDRHVDVLNL CFAQFEPDST 240
EYIKVHHKTY EDIDKRGKYD LLRSTRYFGG MVWYFVNNKK IDGLLIDQIQ RDLIDDATNL 300
VQLYHVLHPD GQSAQGAKDQ AAEGINLIKV FAKTEAQKGA YIELTLQTYQ EALSRHSAAS 360 
Gene Ontology
 GO:0005763; C:mitochondrial small ribosomal subunit; IDA:MGI.
 GO:0003735; F:structural constituent of ribosome; IDA:MGI. 
Interpro
 IPR019374; Ribosomal_S22_mit. 
Pfam
 PF10245; MRP-S22 
SMART
  
PROSITE
  
PRINTS