CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-042499
UniProt Accession
H0Y7W4_HUMAN
;
H0Y7W4
Genbank Protein ID
U52111
Genbank Nucleotide ID
Protein Name
Dual specificity protein phosphatase
Protein Synonyms/Alias
Gene Name
DUSP9
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Lysine Modification
Position
Peptide
Type
References
292
NDAYDLV
K
RKKSNIS
ubiquitination
[1]
Reference
[1] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [
PMID: 21963094
]
Functional Description
Sequence Annotation
ACT_SITE 261 261 Phosphocysteine intermediate (By
Keyword
Complete proteome; Hydrolase; Protein phosphatase; Reference proteome.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
355 AA
Protein Sequence
XSLASSLRNK EGTLGSKVGY LDVEARGPGE GRGGGGESPP LQPPPPAPVL LYDQGGGRRR 60
RGEAEAEAEE WEAESVLGTL LQKLREEGYL AYYLQGGFSR FQAECPHLCE TSLAGRAGSS 120
MAPVPGPVPV VGLGSLCLGS DCSDAESEAD RDSMSCGLDS EGATPPPVGL RASFPVQILP 180
NLYLGSARDS ANLESLAKLG IRYILNVTPN LPNFFEKNGD FHYKQIPISD HWSQNLSRFF 240
PEAIEFIDEA LSQNCGVLVH CLAGVSRSVT VTVAYLMQKL HLSLNDAYDL VKRKKSNISP 300
NFNFMGQLLD FERSLRLEER HSQEQGSGGQ ASAASNPPSF FTTPTSDGAF ELAPT 355
Gene Ontology
GO:0005783
; C:endoplasmic reticulum; IDA:HPA.
GO:0017017
; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
GO:0004725
; F:protein tyrosine phosphatase activity; IEA:EC.
GO:0035335
; P:peptidyl-tyrosine dephosphorylation; IEA:GOC.
Interpro
IPR000340
; Dual-sp_phosphatase_cat-dom.
IPR020422
; Dual-sp_phosphatase_subgr_cat.
IPR024950
; DUSP.
IPR008343
; MKP.
IPR001763
; Rhodanese-like_dom.
IPR000387
; Tyr/Dual-sp_Pase.
Pfam
PF00782
; DSPc
SMART
SM00195
; DSPc
PROSITE
PS50056
; TYR_PHOSPHATASE_2
PS50054
; TYR_PHOSPHATASE_DUAL
PRINTS
PR01764
; MAPKPHPHTASE.