| Tag | Content |
|---|
| CPLM ID | CPLM-006554 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta |
Protein Synonyms/Alias | GMP-PDE beta |
Gene Name | PDE6B |
Gene Synonyms/Alias | PDEB |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 681 | KKRAMFQKIVDESKN | ubiquitination | [1] | | 817 | LADEYEAKVKALEEK | ubiquitination | [1] | | 834 | EERVAAKKVGTEICN | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme. |
Sequence Annotation | DOMAIN 71 220 GAF 1.
DOMAIN 252 429 GAF 2.
ACT_SITE 557 557 Proton donor (By similarity).
METAL 561 561 Divalent metal cation 1 (By similarity).
METAL 597 597 Divalent metal cation 1 (By similarity).
METAL 598 598 Divalent metal cation 1 (By similarity).
METAL 598 598 Divalent metal cation 2 (By similarity).
METAL 718 718 Divalent metal cation 1 (By similarity).
MOD_RES 2 2 N-acetylserine (By similarity).
LIPID 851 851 S-geranylgeranyl cysteine (By |
Keyword | Acetylation; Alternative splicing; cGMP; Complete proteome; Congenital stationary night blindness; Disease mutation; Hydrolase; Lipoprotein; Membrane; Metal-binding; Polymorphism; Prenylation; Reference proteome; Repeat; Retinitis pigmentosa; Sensory transduction; Vision. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 854 AA |
Protein Sequence | MSLSEEQARS FLDQNPDFAR QYFGKKLSPE NVAAACEDGC PPDCDSLRDL CQVEESTALL 60
ELVQDMQESI NMERVVFKVL RRLCTLLQAD RCSLFMYRQR NGVAELATRL FSVQPDSVLE 120
DCLVPPDSEI VFPLDIGVVG HVAQTKKMVN VEDVAECPHF SSFADELTDY KTKNMLATPI 180
MNGKDVVAVI MAVNKLNGPF FTSEDEDVFL KYLNFATLYL KIYHLSYLHN CETRRGQVLL 240
WSANKVFEEL TDIERQFHKA FYTVRAYLNC ERYSVGLLDM TKEKEFFDVW SVLMGESQPY 300
SGPRTPDGRE IVFYKVIDYV LHGKEEIKVI PTPSADHWAL ASGLPSYVAE SGFICNIMNA 360
SADEMFKFQE GALDDSGWLI KNVLSMPIVN KKEEIVGVAT FYNRKDGKPF DEQDEVLMES 420
LTQFLGWSVM NTDTYDKMNK LENRKDIAQD MVLYHVKCDR DEIQLILPTR ARLGKEPADC 480
DEDELGEILK EELPGPTTFD IYEFHFSDLE CTELDLVKCG IQMYYELGVV RKFQIPQEVL 540
VRFLFSISKG YRRITYHNWR HGFNVAQTMF TLLMTGKLKS YYTDLEAFAM VTAGLCHDID 600
HRGTNNLYQM KSQNPLAKLH GSSILERHHL EFGKFLLSEE TLNIYQNLNR RQHEHVIHLM 660
DIAIIATDLA LYFKKRAMFQ KIVDESKNYQ DKKSWVEYLS LETTRKEIVM AMMMTACDLS 720
AITKPWEVQS KVALLVAAEF WEQGDLERTV LDQQPIPMMD RNKAAELPKL QVGFIDFVCT 780
FVYKEFSRFH EEILPMFDRL QNNRKEWKAL ADEYEAKVKA LEEKEEEERV AAKKVGTEIC 840
NGGPAPKSST CCIL 854 |
Gene Ontology | GO:0097381; C:photoreceptor disc membrane; TAS:Reactome. GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IMP:BHF-UCL. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0007596; P:blood coagulation; TAS:Reactome. GO:0051480; P:cytosolic calcium ion homeostasis; IMP:BHF-UCL. GO:0046037; P:GMP metabolic process; IMP:BHF-UCL. GO:0007603; P:phototransduction, visible light; TAS:ProtInc. GO:0060041; P:retina development in camera-type eye; IEA:Compara. GO:0007601; P:visual perception; TAS:ProtInc. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |