CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006939
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interferon gamma receptor 2 
Protein Synonyms/Alias
 IFN-gamma receptor 2; IFN-gamma-R2; Interferon gamma receptor accessory factor 1; AF-1; Interferon gamma transducer 1 
Gene Name
 IFNGR2 
Gene Synonyms/Alias
 IFNGT1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
328SIISFPEKEQEDVLQubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. 
Sequence Annotation
 DOMAIN 31 129 Fibronectin type-III 1.
 DOMAIN 139 229 Fibronectin type-III 2.
 CARBOHYD 56 56 N-linked (GlcNAc...) (Potential).
 CARBOHYD 85 85 N-linked (GlcNAc...) (Potential).
 CARBOHYD 110 110 N-linked (GlcNAc...) (Potential).
 CARBOHYD 137 137 N-linked (GlcNAc...) (Potential).
 CARBOHYD 219 219 N-linked (GlcNAc...) (Potential).
 CARBOHYD 231 231 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Disease mutation; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 337 AA 
Protein Sequence
MRPTLLWSLL LLLGVFAAAA AAPPDPLSQL PAPQHPKIRL YNAEQVLSWE PVALSNSTRP 60
VVYQVQFKYT DSKWFTADIM SIGVNCTQIT ATECDFTAAS PSAGFPMDFN VTLRLRAELG 120
ALHSAWVTMP WFQHYRNVTV GPPENIEVTP GEGSLIIRFS SPFDIADTST AFFCYYVHYW 180
EKGGIQQVKG PFRSNSISLD NLKPSRVYCL QVQAQLLWNK SNIFRVGHLS NISCYETMAD 240
ASTELQQVIL ISVGTFSLLS VLAGACFFLV LKYRGLIKYW FHTPPSIPLQ IEEYLKDPTQ 300
PILEALDKDS SPKDDVWDSV SIISFPEKEQ EDVLQTL 337 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004906; F:interferon-gamma receptor activity; TAS:ProtInc.
 GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0009615; P:response to virus; TAS:ProtInc. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR015373; Interferon_alpha/beta_rcpt_bsu. 
Pfam
 PF09294; Interfer-bind 
SMART
 SM00060; FN3 
PROSITE
 PS50853; FN3 
PRINTS