UniProt Accession

 CATL1_HUMAN; P07711; Q6IAV1; Q96QJ0 

Genbank Protein ID

 X12451; M20496; CR457053; BX537395; AL160279; BC012612; X05256 

Genbank Nucleotide ID

 CAA30981.1; AAA66974.1; CAG33334.1; CAD97637.1; CAI16308.1; AAH12612.1; CAA28877.1 

Protein Name

 Cathepsin L1 

Protein Synonyms/Alias

 Major excreted protein; MEP; Cathepsin L1 heavy chain; Cathepsin L1 light chain 

Gene Name

 CTSL1 

Gene Synonyms/Alias

 CTSL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
104	NRKPRKGKVFQEPLF	ubiquitination	[1]
216	ESCKYNPKYSVANDT	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Important for the overall degradation of proteins in lysosomes. 

Sequence Annotation

 ACT_SITE 138 138
 ACT_SITE 276 276
 ACT_SITE 300 300
 CARBOHYD 221 221 N-linked (GlcNAc...).
 DISULFID 135 178
 DISULFID 169 211
 DISULFID 269 322 Interchain (between heavy and light  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease; Reference proteome; Signal; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 333 AA 

Protein Sequence

Gene Ontology

 GO:0036021; C:endolysosome lumen; TAS:Reactome.
 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0005634; C:nucleus; TAS:BHF-UCL.
 GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
 GO:0042393; F:histone binding; IDA:BHF-UCL.
 GO:0002250; P:adaptive immune response; IEP:UniProtKB.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IEP:UniProtKB.
 GO:0030574; P:collagen catabolic process; TAS:Reactome.
 GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0071888; P:macrophage apoptotic process; NAS:BHF-UCL.
 GO:0006508; P:proteolysis; IDA:UniProtKB.
 GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome. 

Interpro

 IPR025661; Pept_asp_AS.
 IPR000169; Pept_cys_AS.
 IPR025660; Pept_his_AS.
 IPR013128; Peptidase_C1A.
 IPR000668; Peptidase_C1A_C.
 IPR013201; Prot_inhib_I29. 

Pfam

 PF08246; Inhibitor_I29
 PF00112; Peptidase_C1 

SMART

 SM00848; Inhibitor_I29
 SM00645; Pept_C1 

PROSITE

 PS00640; THIOL_PROTEASE_ASN
 PS00139; THIOL_PROTEASE_CYS
 PS00639; THIOL_PROTEASE_HIS 

PRINTS

 PR00705; PAPAIN.