UniProt Accession

 DDX51_HUMAN; Q8N8A6; A8MPT9; Q5CZ71; Q8IXK5; Q96ED1 

Genbank Protein ID

 AK097078; AC138466; BC012461; BC040185; CR936870 

Genbank Nucleotide ID

 BAC04942.1; AAH12461.2; AAH40185.1; CAI59782.1 

Protein Name

 ATP-dependent RNA helicase DDX51 

Protein Synonyms/Alias

 DEAD box protein 51 

Gene Name

 DDX51 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
211	DVHPDLQKQLRAHGI	ubiquitination	[1, 2]
291	ALVVLPTKELAQQVS	ubiquitination	[2]
299	ELAQQVSKVFNIYTD	ubiquitination	[2]
319	VSLVTGQKSLAKEQE	ubiquitination	[2]
331	EQESLVQKTADGYRC	ubiquitination	[2]
440	TLTQNPEKLQQLGLH	ubiquitination	[2]
601	GRTARAGKTGQAFTL	ubiquitination	[2]
637	QRHELSSKLLQPLVP	ubiquitination	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits (By similarity). 

Sequence Annotation

 DOMAIN 243 452 Helicase ATP-binding.
 DOMAIN 494 640 Helicase C-terminal.
 NP_BIND 256 263 ATP (By similarity).
 MOTIF 221 229 Q motif.
 MOTIF 371 374 DEAD box.
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 103 103 Phosphoserine.  

Keyword

 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 666 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000629; RNA-helicase_DEAD-box_CS. 

Pfam

 PF00270; DEAD
 PF00271; Helicase_C 

SMART

 SM00487; DEXDc
 SM00490; HELICc 

PROSITE

 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 

PRINTS