UniProt Accession

 INSRR_MOUSE; Q9WTL4; B2RQC5 

Genbank Protein ID

 AB007135; CH466547; BC137855 

Genbank Nucleotide ID

 BAA77835.1; EDL15346.1; AAI37856.1 

Protein Name

 Insulin receptor-related protein 

Protein Synonyms/Alias

 IRR; IR-related receptor; Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain 

Gene Name

 Insrr 

Gene Synonyms/Alias

 Irr 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
1013	ESTPVALKTVNELAS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. 

Sequence Annotation

 DOMAIN 484 594 Fibronectin type-III 1.
 DOMAIN 605 695 Fibronectin type-III 2.
 DOMAIN 815 911 Fibronectin type-III 3.
 DOMAIN 979 1254 Protein kinase.
 NP_BIND 985 993 ATP (By similarity).
 ACT_SITE 1115 1115 Proton acceptor (By similarity).
 BINDING 1013 1013 ATP (By similarity).
 MOD_RES 1145 1145 Phosphotyrosine; by autocatalysis (By
 MOD_RES 1146 1146 Phosphotyrosine; by autocatalysis (By
 CARBOHYD 47 47 N-linked (GlcNAc...) (Potential).
 CARBOHYD 100 100 N-linked (GlcNAc...) (Potential).
 CARBOHYD 311 311 N-linked (GlcNAc...) (Potential).
 CARBOHYD 411 411 N-linked (GlcNAc...) (Potential).
 CARBOHYD 492 492 N-linked (GlcNAc...) (Potential).
 CARBOHYD 528 528 N-linked (GlcNAc...) (Potential).
 CARBOHYD 616 616 N-linked (GlcNAc...) (Potential).
 CARBOHYD 634 634 N-linked (GlcNAc...) (Potential).
 CARBOHYD 756 756 N-linked (GlcNAc...) (Potential).
 CARBOHYD 885 885 N-linked (GlcNAc...) (Potential).
 CARBOHYD 898 898 N-linked (GlcNAc...) (Potential).
 DISULFID 214 222 By similarity.
 DISULFID 216 228 By similarity.
 DISULFID 229 237 By similarity.
 DISULFID 233 246 By similarity.
 DISULFID 249 258 By similarity.
 DISULFID 262 274 By similarity.
 DISULFID 280 300 By similarity.
 DISULFID 304 317 By similarity.
 DISULFID 320 324 By similarity.
 DISULFID 657 864 Interchain (between alpha and beta  

Keyword

 ATP-binding; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1300 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; ISS:UniProtKB.
 GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.
 GO:0071469; P:cellular response to alkalinity; IDA:UniProtKB.
 GO:0030238; P:male sex determination; IMP:MGI.
 GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. 

Interpro

 IPR000494; EGF_rcpt_L.
 IPR003961; Fibronectin_type3.
 IPR006211; Furin-like_Cys-rich_dom.
 IPR006212; Furin_repeat.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR013783; Ig-like_fold.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016246; Tyr_kinase_insulin-like_rcpt.
 IPR002011; Tyr_kinase_rcpt_2_CS. 

Pfam

 PF00041; fn3
 PF00757; Furin-like
 PF07714; Pkinase_Tyr
 PF01030; Recep_L_domain 

SMART

 SM00060; FN3
 SM00261; FU
 SM00219; TyrKc 

PROSITE

 PS50853; FN3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00239; RECEPTOR_TYR_KIN_II 

PRINTS

 PR00109; TYRKINASE.