CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024693
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inward rectifier potassium channel 18 
Protein Synonyms/Alias
 Inward rectifier K(+) channel Kir2.6; Potassium channel, inwardly rectifying subfamily J member 18 
Gene Name
 KCNJ18 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
366AKDLVENKFLLPSANubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. 
Sequence Annotation
  
Keyword
 Cell membrane; Complete proteome; Disease mutation; Ion channel; Ion transport; Membrane; Phosphoprotein; Polymorphism; Potassium; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 433 AA 
Protein Sequence
MTAASQANPY SIVSLEEDGL HLVTMSGAKG FGNGKVHTQH RCRNRFVKKN GQCNIAFANM 60
DEKSQRYLAD MFTTCVDIRW RYMLLIFSLA FLASWLLFGV IFWVIAVAHG DLEPAEGHGR 120
TPCVMQVHGF MAAFLFSIET QTTIGYGLRC VTEECLVAVF MVVAQSIVGC IIDSFMIGAI 180
MAKMARPKKR AHTLLFSHNA VVALRDGKLC LMWRVGNLRK SHIVEAHVRA QLIKPRVTEE 240
GEYIPLDQVD IDVGFDKGLD RIFLVSPITI LHEIDEASPL LGISRQDLET DDFEIVVILE 300
GMVEATAMTT QARSSYLANE ILWGHRFEPV LFEEKNQFKI DHSHFHKTYE VPSTPRCSAK 360
DLVENKFLLP SANSFCYENE LAFLSRDEED EADGDQDGRS RDGLSPQARH DFDRLQAGGG 420
VLEQRPYRRG SEI 433 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005242; F:inward rectifier potassium channel activity; IDA:UniProtKB. 
Interpro
 IPR014756; Ig_E-set.
 IPR016449; K_chnl_inward-rec_Kir.
 IPR003272; K_chnl_inward-rec_Kir2.2.
 IPR013518; K_chnl_inward-rec_Kir_cyto.
 IPR013673; K_chnl_inward-rec_Kir_N. 
Pfam
 PF01007; IRK
 PF08466; IRK_N 
SMART
  
PROSITE
  
PRINTS
 PR01325; KIR22CHANNEL.
 PR01320; KIRCHANNEL.