CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005288
UniProt Accession
Genbank Protein ID
 X54467 
Genbank Nucleotide ID
Protein Name
 Cathepsin D 
Protein Synonyms/Alias
 Cathepsin D 12 kDa light chain; Cathepsin D 9 kDa light chain; Cathepsin D 34 kDa heavy chain; Cathepsin D 30 kDa heavy chain 
Gene Name
 Ctsd 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
168KSDLGGIKVEKQIFGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Acid protease active in intracellular protein breakdown. 
Sequence Annotation
 ACT_SITE 97 97 By similarity.
 ACT_SITE 290 290 By similarity.
 CARBOHYD 134 134 N-linked (GlcNAc...) (Potential).
 CARBOHYD 258 258 N-linked (GlcNAc...) (Potential).
 DISULFID 91 160 By similarity.
 DISULFID 110 117 By similarity.
 DISULFID 281 285 By similarity.
 DISULFID 324 361 By similarity.  
Keyword
 Aspartyl protease; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease; Reference proteome; Secreted; Signal; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 407 AA 
Protein Sequence
MQTPGVLLLI LGLLDASSSA LIRIPLRKFT SIRRTMTEVG GSVEDLILKG PITKYSMQSS 60
PRTKEPVSEL LKNYLDAQYY GEIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KLLDIACWVH 120
HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC KSDLGGIKVE KQIFGEATKQ 180
PGVVFIAAKF DGILGMGYPF ISVNKVLPVF DNLMKQKLVE KNIFSFYLNR DPTGQPGGEL 240
MLGGTDSRYY HGELSYLNVT RKAYWQVHMD QLEVGSELTL CKGGCEAIVD TGTSLLVGPV 300
DEVKELQKAI GAVPLIQGEY MIPCEKVSSL PIITFKLGGQ NYELHPEKYI LKVSQAGKTI 360
CLSGFMGMDI PPPSGPLWIL GDVFIGCYYT VFDREYNRVG FAKAATL 407 
Gene Ontology
 GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IDA:RGD.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0004175; F:endopeptidase activity; IDA:RGD.
 GO:0042277; F:peptide binding; IDA:RGD.
 GO:0006914; P:autophagy; IEP:RGD.
 GO:0006508; P:proteolysis; IDA:RGD. 
Interpro
 IPR001461; Peptidase_A1.
 IPR021109; Peptidase_aspartic.
 IPR001969; Peptidase_aspartic_AS.
 IPR012848; Propep_A1. 
Pfam
 PF07966; A1_Propeptide
 PF00026; Asp 
SMART
  
PROSITE
 PS00141; ASP_PROTEASE 
PRINTS
 PR00792; PEPSIN.