UniProt Accession

 STML2_RAT; Q4FZT0 

Genbank Protein ID

 BC099164 

Genbank Nucleotide ID

 AAH99164.1 

Protein Name

 Stomatin-like protein 2, mitochondrial 

Protein Synonyms/Alias

 SLP-2 

Gene Name

 Stoml2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
114	LRIMDPYKASYGVED	acetylation	[1]
140	TMRSELGKLSLDKVF	acetylation	[1]
145	LGKLSLDKVFRERES	acetylation	[1]
221	AINVAEGKKQAQILA	acetylation	[1]
233	ILASEAEKAEQINQA	acetylation	[1]
250	EASAVLAKAKAKAEA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation (By similarity). 

Sequence Annotation

 MOD_RES 17 17 Phosphoserine; by PKC/PRKCZ (By
 MOD_RES 124 124 Phosphotyrosine (By similarity).
 MOD_RES 145 145 N6-acetyllysine (By similarity).
 MOD_RES 233 233 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Cell membrane; Coiled coil; Complete proteome; Direct protein sequencing; Lipid-binding; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 353 AA 

Protein Sequence

Gene Ontology

 GO:0019897; C:extrinsic to plasma membrane; ISS:UniProtKB.
 GO:0045121; C:membrane raft; ISS:UniProtKB.
 GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
 GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
 GO:0008180; C:signalosome; IEA:Compara.
 GO:1901612; F:cardiolipin binding; ISS:UniProtKB.
 GO:0035710; P:CD4-positive, alpha-beta T cell activation; ISS:UniProtKB.
 GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB.
 GO:0032623; P:interleukin-2 production; ISS:UniProtKB.
 GO:0010876; P:lipid localization; ISS:UniProtKB.
 GO:0042776; P:mitochondrial ATP synthesis coupled proton transport; ISS:UniProtKB.
 GO:0006851; P:mitochondrial calcium ion transport; ISS:UniProtKB.
 GO:0034982; P:mitochondrial protein processing; ISS:UniProtKB.
 GO:1900210; P:positive regulation of cardiolipin metabolic process; ISS:UniProtKB.
 GO:0090297; P:positive regulation of mitochondrial DNA replication; ISS:UniProtKB.
 GO:0010918; P:positive regulation of mitochondrial membrane potential; ISS:UniProtKB.
 GO:0051259; P:protein oligomerization; ISS:UniProtKB.
 GO:1990046; P:stress-induced mitochondrial fusion; ISS:UniProtKB.
 GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB. 

Interpro

 IPR001107; Band_7.
 IPR001972; Stomatin. 

Pfam

 PF01145; Band_7 

SMART

 SM00244; PHB 

PROSITE

  

PRINTS

 PR00721; STOMATIN.