CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023534
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Apelin receptor 
Protein Synonyms/Alias
 Angiotensin receptor-like 1; G-protein coupled receptor APJ; MSR 
Gene Name
 Aplnr 
Gene Synonyms/Alias
 Agtrl1; Apj 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
366GGEQMHEKSIPYSQEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. 
Sequence Annotation
 CARBOHYD 13 13 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell membrane; Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MEDDGYNYYG ADNQSECDYA DWKPSGALIP AIYMLVFLLG TTGNGLVLWT VFRTSREKRR 60
SADIFIASLA VADLTFVVTL PLWATYTYRE FDWPFGTFSC KLSSYLIFVN MYASVFCLTG 120
LSFDRYLAIV RPVANARLRL RVSGAVATAV LWVLAALLAV PVMVFRSTDA SENGTKIQCY 180
MDYSMVATSN SEWAWEVGLG VSSTAVGFVV PFTIMLTCYF FIAQTIAGHF RKERIEGLRK 240
RRRLLSIIVV LVVTFALCWM PYHLVKTLYM LGSLLHWPCD FDIFLMNVFP YCTCISYVNS 300
CLNPFLYAFF DPRFRQACTS MLCCDQSGCK GTPHSSSAEK SASYSSGHSQ GPGPNMGKGG 360
EQMHEKSIPY SQETLVD 377 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
 GO:0050878; P:regulation of body fluid levels; IEA:Compara. 
Interpro
 IPR020279; Apelin_receptor_C.
 IPR003904; APJ_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR01416; APJRECEPTOR.
 PR00237; GPCRRHODOPSN.