| Tag | Content |
|---|
| CPLM ID | CPLM-012991 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Gamma-secretase-activating protein |
Protein Synonyms/Alias | GSAP; Protein pigeon homolog; Gamma-secretase-activating protein 16 kDa C-terminal form; GSAP-16K |
Gene Name | Gsap |
Gene Synonyms/Alias | Pion |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 258 | TLTGLRFKLVNFGYD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta- amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Golgi apparatus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 858 AA |
Protein Sequence | MALRLVTHFD VLEDVLPSLL TQAATTDEGD RAGVLETTYG SLRVLNIERN GNIIYTYKDN 60
KGNAVFGLYD CQTRQNEHLY TFEKDMQAVS CSVNSERTVL AASFIQYTTE GVKNDLQPGS 120
KCLTLLVEIH PVNNVKVLKA VDSCVWVQFL YPQAESHLLP QNHLLLISEE KYIERFHIQI 180
TREDGDRVVI RNSSHLPRDR LAEDFVWAQW DLSEQRLYYI ELKESRSILK CIQFRADESF 240
NLMFEMPLDI TLTGLRFKLV NFGYDYRQDR EKLCNQPSLC IFTNHTGSLC MCYSPKSDSR 300
EEITYSVFYL HKGYRKIFTA APGSADSQVT NGADSQVTDG IAFLNLGYFV AVYSPGHFLH 360
LLNIQHPDLV CHSLFLTGNN KIAAVLPPSP LQSLPGSLVL DCYSGKVYRV TLDQSYLLRF 420
LWNAHLDCER MAALHCILSC SQDPGFPEEQ IIQWISEHVS ACHSFDLIQE FLIASSYWSV 480
YAELDDMGML LQYSSVLTWN TEIPGIKFTT EELPLPLMKV YGLKGYWAKL NSNLEYIKYT 540
KPHLHYHNSV VRREWHNLIS EERTGKRRST MYVRNILENA MKVIASMETR TLEPRLIPFL 600
QEEDRHQRLL MGLMVSELRD HLLRHLQGVE KKKIEQMVLD YISKLLDLIW CLLETSWRKH 660
SMHPLVLHLN SHCSAADFEV FHLMTRILDA ASSLCLPLPP GFHSLHTILG VHCLPLYSLL 720
HYIDNGVLLL TETAVTRLMK DLDNSEKNEQ LKFSIIVRLP PLIGQKVCRL WDHPMSSNII 780
SRNHVARLLK NYRKEPRNSM IDKSSFPVEF LPLNYFIEIL MGLESSNQAL YGFEGHDNVD 840
AEFVEEAALK HTTMLLGL 858 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0005802; C:trans-Golgi network; ISS:UniProtKB. GO:0001540; F:beta-amyloid binding; ISS:UniProtKB. GO:0034205; P:beta-amyloid formation; IDA:UniProtKB. GO:0030162; P:regulation of proteolysis; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |