UniProt Accession

 CD63_MOUSE; P41731 

Genbank Protein ID

 D16432; BC008108; BC012212; BC083161 

Genbank Nucleotide ID

 BAA03904.1; AAH08108.1; AAH12212.1; AAH83161.1 

Protein Name

 CD63 antigen 

Protein Synonyms/Alias

 CD63 

Gene Name

 Cd63 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
117	QVKSEFNKSFQQQMQ	ubiquitination	[1]
128	QQMQNYLKDNKTATI	ubiquitination	[1]
138	KTATILDKLQKENNC	acetylation	[2, 3]
138	KTATILDKLQKENNC	succinylation	[3]
138	KTATILDKLQKENNC	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 May play some role in signal transduction pathways. 

Sequence Annotation

 CARBOHYD 116 116 N-linked (GlcNAc...) (Potential).
 CARBOHYD 130 130 N-linked (GlcNAc...).
 CARBOHYD 150 150 N-linked (GlcNAc...) (Potential).
 CARBOHYD 172 172 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell membrane; Complete proteome; Endosome; Glycoprotein; Lysosome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 238 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IEA:Compara.
 GO:0010008; C:endosome membrane; ISO:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005770; C:late endosome; IDA:MGI.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0034613; P:cellular protein localization; ISO:MGI.
 GO:2000680; P:regulation of rubidium ion transport; ISO:MGI. 

Interpro

 IPR000301; Tetraspanin.
 IPR018499; Tetraspanin/Peripherin.
 IPR018503; Tetraspanin_CS.
 IPR008952; Tetraspanin_EC2. 

Pfam

 PF00335; Tetraspannin 

SMART

  

PROSITE

 PS00421; TM4_1 

PRINTS

 PR00259; TMFOUR.