CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010738
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60S acidic ribosomal protein P2 
Protein Synonyms/Alias
  
Gene Name
 Rplp2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
21GNSSPSAKDIKKILDacetylation[1, 2, 3, 4, 5]
21GNSSPSAKDIKKILDsuccinylation[4]
21GNSSPSAKDIKKILDubiquitination[6]
24SPSAKDIKKILDSVGacetylation[3, 5]
25PSAKDIKKILDSVGIubiquitination[6]
41ADDDRLNKVISELNGacetylation[5]
41ADDDRLNKVISELNGubiquitination[6]
49VISELNGKNIEDVIAacetylation[3, 7]
49VISELNGKNIEDVIAubiquitination[6]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
 Plays an important role in the elongation step of protein synthesis. 
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 17 17 Phosphoserine.
 MOD_RES 21 21 N6-acetyllysine (By similarity).
 MOD_RES 79 79 Phosphoserine (By similarity).
 MOD_RES 86 86 Phosphoserine (By similarity).
 MOD_RES 102 102 Phosphoserine.
 MOD_RES 105 105 Phosphoserine.  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 115 AA 
Protein Sequence
MRYVASYLLA ALGGNSSPSA KDIKKILDSV GIEADDDRLN KVISELNGKN IEDVIAQGVG 60
KLASVPAGGA VAVSAAPGSA APAAGSAPAA AEEKKDEKKE ESEESDDDMG FGLFD 115 
Gene Ontology
 GO:0022625; C:cytosolic large ribosomal subunit; IEA:Compara.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006414; P:translational elongation; IEA:InterPro. 
Interpro
 IPR001813; Ribosomal_L10/L12.
 IPR027534; Ribosomal_L12. 
Pfam
 PF00428; Ribosomal_60s 
SMART
  
PROSITE
  
PRINTS